一种高效合成5种钙卟啉的新方法及作用机制  

A novel method for highly efficient synthesis of five calcium porphyrins and the reaction mechanism of KOH

作　　者：王梅[1] 佘远斌[1] 周贤太[2] 纪红兵[2] 

机构地区：[1]北京工业大学环能学院绿色化学与精细化工研究所,北京100124 [2]中山大学化学与化学工程学院,广东广州510275

出　　处：《化学试剂》2012年第8期685-687,698,共4页Chemical Reagents

基　　金：国家自然科学基金重点和面上项目(20776003;21036009;21076004和20976203);北京市绿色化工学术创新团队计划资助项目(PHR201107104)

摘　　要：采用改进的液相法,以KOH为催化剂、卟啉配体和Ca(OAc)2.H2O为原料,研究了高效合成5种钙卟啉的新方法,并对KOH的催化作用机制进行了深入的探讨。经1HNMR、UV-Vis和MS表征,确认了所合成产物的结构正确,且本方法与钙卟啉的其他合成方法相比,在KOH的特殊催化作用下,可使合成反应的时间从10 h减少到0.5 h,而卟啉配体金属化时的转化率则从75%增加至99%。A novel liquid-phase method for synthesizing calci- um porphyrins was developed and used to highly efficiently synthesis of five calcium porphyrins by the reaction of free base and Ca （OAc）2, and the catalytic mechanism of KOH was further investigated. The structures of five calcium por- phyrins were characterized J HNMR, UV-vis and MS. With comparison to other methods for synthesizing calcium porphy- tin, this novel liquid-phase method in the presence of KOH could shorten reaction time from 10 h to 30 min, while the conversion of free base increased from 75% to 99%.

关 键 词：KOH 催化 钙卟啉 高效合成 

分 类 号：O627.22[理学—有机化学]