7-溴-6-氯-4(3H)-喹诺酮的合成  

Synthesis and characterization of 7-bromo-6-chloro-4(3H)-quinazolinone

作　　者：王严飞[1,2] 余勃[2] 唐楚颖[2] 陆豫[2] 

机构地区：[1]南昌大学环境与化学工程学院,江西南昌330031 [2]南昌大学中德联合研究院,江西南昌330047

出　　处：《化学试剂》2012年第8期750-752,共3页Chemical Reagents

摘　　要：球虫病是一种对家禽肠道有损害的寄生虫病。常山酮是一种较好的抗球虫药物,但是长期以来由于价格昂贵,限制了其在临床上的广泛应用。7-溴-6-氯-4(3H)-喹诺酮是合成抗球虫药物常山酮的重要中间体。以间氯甲苯作为起始原料,经溴化、氧化、氨化、环化共4步反应,合成了标题化合物,总收率50.61%。并用MS和1HNMR进行了结构表征。Coccidiosis is such a disease which is a danger to the intestinal parasitic of poultry. And Halofuginone is rather an effective drug against coccidian. But its high cost is really a block for its wide application in clinical practice. 7-bromo- 6-chloro-4 （ 3H ）-quinazolinone is an important intermediate for the synthesis of the anti-coccidiosis drug-halofuginone. This work has a new idea. The research applies inter-chloro- toluene as the primary materials. And after the reaction of bro- minating, oxidation, ammo-niation and cyclization, then 7-bro- mo-6-ehloro-4 （ 3H ） -quinazolinone was synthesized. The total yield will reach 50. 61% and the structure was confirmed via MS and IHNMR.

关 键 词：球虫病 常山酮 中间体 7-溴-6-氯4(3H)-喹诺酮 

分 类 号：TQ460.31[化学工程—制药化工]