妊娠期糖尿病产后血糖转归与瘦素水平相关性研究  

Relationship Between Leptin and 6 Postpartum Glucose Metabolism in Gestational Diabetes

作　　者：卫梦南[1] 吴艳丽[1] 饶明礼[1] 王一清[1] 刘建[1] 

机构地区：[1]重庆医科大学第二附属医院产科,重庆400010

出　　处：《昆明医学院学报》2012年第6期62-65,69,共5页Journal of Kunming Medical College

基　　金：云南省应用基础研究基金资助项目(2009ZC116M)

摘　　要：目的分析妊娠期糖尿病(GDM)孕妇产后42 d 75 g葡萄糖耐量实验(OGTT)结果,探讨其与瘦素水平间关系.方法收集2011年4～11月重庆医科大学第二附属医院产科36例GDM孕妇的临床资料,根据产后42 d行75 g葡萄糖耐量实验(75 g OGTT)的结果分2组(血糖浓度正常组(Ⅰ组)和不正常组(Ⅱ组)),检测空腹胰岛素、瘦素,进行统计分析.结果Ⅰ组产后空腹血糖明显低于Ⅱ组(P<0.05),瘦素水平明显高于Ⅱ组(P<0.05).2组间年龄、BMI、空腹胰岛素、HOMA-IR无明显差异(P>0.05).多元线性回归分析结果表明:瘦素与空腹血糖存在明显负相关性(R=-0.51,P=0.02),与HOMA-IR存在明显正相关性(R=0.7,P=0.003).BMI、年龄等与空腹血糖、HOMA-IR均没有显著相关性.一元线性回归结果表明:空腹血糖与HOMA-IR存在明显负相关性(R=-0.56,P=0.01).瘦素与空腹胰岛素间存在显著正相关性(R=0.73,P=0.001).结论Ⅰ组产后空腹血糖明显低于Ⅱ组,瘦素水平明显高于Ⅱ组.瘦素水平与空腹血糖存在明显负相关性,与HOMA-IR存在明显正相关性.BMI年龄与空腹血糖、HOMA-IR无显著相关性.Objective To analyze the results of the 75g oral glucose tolerance test （OGTY） in gestational diabetes mellitus （GDM） at six weeks after delivering to investigate the relationship between the leptin and 6 weeks postpartum glucose metabolism in gestational diabetes. Methods A retrospective study was conducted on the clin- ical data of 36 women with GDM, who delivered and underwent a 2 hours 75g OGTI＂ at 42 days postpartum from April to November in 2011 in our hospital. On the basis of the results of OGTT, they were reclassified into two groups （normal group （I group） and abnormal group （II group） to test leptin and fasting insulin levels. Results In the I group, the mean fasting blood-glucose level was much lower than that of the ]l group （P 〈 0.05） , and the mean leptin concentration was significantly higher than that of the [I group （P 〈 0.05）. There was not significant differ- ences in age, BMI, fasting blood-insulin and HOMA-IR between two groups. The multiple logistic regression model showed that the leptin concentratiodn was significantly negatively correlated with fasting blood-glucose （R = -0.51, P=0.02） , and was significantly positively correlated with HOMA-IR （R = 0.7, P = 0.003）. There was no significant correlation between BMI and age with fasting blood-glucose, so did BMI and age with HOMA-IR.The linear regression model showed that the fasting blood-glucose was significantly negatively correlated （R =-0.56, P = 0.01） with HOMA-IR, the leptin concentratiodn was significantly positively correlated with fasting blood-in-sulin concentration （R = 0.73, P = 0.001 ）. Conclusion In the I group, the mean fasting blood-glucose is much lower than that of the 11 group, the mean leptin concentration is significantly higher than that of the ]I group. The leptin concentratiodn is significantly negatively correlated with fasting blood-glucose, and is significantly positively correlated with HOMA-IR. There is no significant correlation between BMI and age with fasting

关 键 词：妊娠期糖尿病 产后 糖代谢 瘦素 

分 类 号：R714.256[医药卫生—妇产科学]