新型可降解硫酸钙/聚酰胺复合材料的制备和表征  

Study on preparation and properties of novel degradable calcium sulphate/polyamide composite

作　　者：刘少英[1] 赵志通[1] 严永刚[1] 吕国玉[1] 

机构地区：[1]四川大学物理科学与技术学院,四川成都610065

出　　处：《功能材料》2012年第15期1989-1993,1997,共6页Journal of Functional Materials

基　　金：国家科技支撑计划资助项目(2007BAE13B00)

摘　　要：以6-氨基己酸(6-aminohexanoic acid,N6)和丁内酰胺(又名α-吡咯烷酮,α-pyrrolidone,α-P)为原料,通过6-氨基己酸熔融缩聚使丁内酰胺开环制备了一系列新型聚酰胺,优化选取6-氨基己酸与丁内酰胺摩尔比为7∶3的聚合物作为基体与硫酸钙(CS)复合,制备了新型可降解硫酸钙/聚酰胺复合材料。通过乌氏粘度计、万能力学实验机、红外光谱(IR)、差示扫描量热分析(DSC)、X射线衍射(XRD)和X光电子能谱(XPS)对其特性黏数、抗压强度及组成与结构进行了表征,并研究了复合材料在磷酸缓冲溶液(PBS)的体外降解性能。结果表明产物为具有酰胺键结构的聚合物,6-氨基己酸与丁内酰胺摩尔比为7∶3时聚合物既能最大程度地引入丁内酰胺又具有较好的力学性能。复合材料无机相与有机相之间存在化学键作用。体外降解实验表明本文合成的聚酰胺是可降解的;相比于聚合物,硫酸钙/聚酰胺复合材料具有更快的降解速率;随着硫酸钙含量的增加,复合材料的失重率增加;在降解过程中降解液pH值维持在6.6～7.4之间。由于复合材料既具备有机组分良好的力学性能又具备硫酸钙良好的生物相容性和降解性能,所以该硫酸钙/聚酰胺复合材料可望在骨修复领域得到运用。A novel biodegradable polyamide was prepared by in ring opening melting polymerization based on 6- aminocaproic acid and a-pyrrolidone, then N6P30 （when the molar ratio of 6-aminocaproic acid and a-pyrroli- done is 7 ： 3） and its composite material with calcium sulfate （CS/N6P30） was synthesized. They were characterized by infrared spectrometer （IR）, X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS） and differential scanning calorimeter （DSC）. Its properties of the viscosity of polymer were investigated by means of ubbelohde viscometer the mechanical properties were characterized by compressive strength and the in vitro degradability of the composite was determined in phosphate buffered saline （PBS）. The results indicated that the polymer was a kind of polyamide, the reaction become more and more difficult with increasing of the proportion of a-pyrrolidone, it has both good mechanical property and the greatest degree of introduction of a-pyrrolidone when the molar ratio of 6-aminocaproic acid and a-pyrroiidone was 7 ：3. PBS experiment indicated that CS/N6P30 was more degradable than N6P30~ degradability of composite materials enhanced with increasing calcium sulfate amount; the pH of soaking medium maintained in the range of 6.6-7.4 during the immersion period. Composite material not only has the good mechanical properties as that of N6P30, but also the biocompatibility as that of CS,so this composite can be potentially used as bone repair materials.

关 键 词：新型聚酰胺 丁内酰胺 复合材料 体外降解 硫酸钙 

分 类 号：TB332[一般工业技术—材料科学与工程]