消旋棉酚晶态结构的研究  

Crystal structure of racemic gossypol

作　　者：吴旭东[1] 唐辉[1] 陈欢[1] 赵红涛[1] 

机构地区：[1]石河子大学药学院,新疆特种植物药资源教育部重点实验室,石河子832002

出　　处：《药物分析杂志》2012年第8期1370-1373,共4页Chinese Journal of Pharmaceutical Analysis

基　　金：兵团博士基金项目(2009JC14);国家教育部重点课题(205815)

摘　　要：目的:研究消旋棉酚晶形结构。方法:采用红外光谱(IR)、差示扫描量热法(DSC)、测定溶解度和粉末X射线衍射法(XRD)来研究消旋棉酚晶态结构。结果:消旋棉酚[(±)G]、左旋棉酚[(-)G]和右旋棉酚[(+)G]的红外谱图基本相同;DSC图谱及热特征数据不一致;在消旋棉酚的饱和溶液中加入光学活性棉酚,光学活性棉酚可以继续溶解,并且有旋光产生;(±)G与(-)G及(+)G的XRD图完全不同。结论:消旋棉酚晶体属于外消旋化合物。Objective：To investigate the crystal structure of racemic gossypol.Methods：The infrared spectroscopy（IR）,differential scanning calorimetery（DSC）,determination of solubility and powder X-ray diffractometry were used to study the crystal structure of racemic gossypol.Results：Racemic gossypol,l-gossypol and d-gossypol had basically the same infrared absorption spectra,but they had different DSC curves and thermal characteristics data.Also when added into a saturated solution of racemic gossypol,the optically active gossypol was dissolved further and optical rotation was created.And the XRD curve of（±） G was completely different from（-） G and from（＋） G.Conclusion：Racemic gossypol is a racemic compound.

关 键 词：消旋棉酚晶态结构 光学活性棉酚 差示扫描量热法 溶解度测定 红外光谱法 高效液相色谱 粉末X射线衍射法 

分 类 号：R917[医药卫生—药物分析学]