慢性乙型肝炎患者病毒复制水平与肝损害程度的关系  

Relationship between viral replication level and degree of liver damage of patients with chronic hepatitis B

作　　者：孔梅[1] 甄君[2] 王莺[3] 

机构地区：[1]中山大学附属第五医院检验科,广东珠海519000 [2]中山大学附属第五医院康复科,广东珠海519000 [3]中山大学附属第五医院内分泌科,广东珠海519000

出　　处：《中华医院感染学杂志》2012年第16期3563-3564,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨不同类型慢性乙型肝炎患者病毒复制水平与肝损害程度的关系。方法随机选取2011年3月-2012年3月轻、中、重度慢性乙型肝炎患者105例,采用荧光标记定量聚合酶链反应方法分别测定血清乙型肝炎病毒DNA(HBV-DNA)含量。结果轻、中、重度血清HBV-DNA含量绝对值的对数值分别为(5.3±1.8)、(6.2±1.3)及(6.7±1.5),差异无统计学意义;不同HBV-DNA含量丙氨酸氨基转氨酶、谷氨酸氨基转移酶及血清总胆红素水平差异无统计学意义。结论不同类型慢性乙型肝炎肝损害程度与血清HBV-DNA基因含量无明显关系。OBJECTIVE To investigate the relationship between the viral replication level and the liver damage of different types of patients with chronic hepatitis B. METHODS A total of 105 patients with mild, moderate, and severe chronic hepatitis B were randomly selected from Mar 2011 to Mar 2012, fluorescently labeled quantitative polymerase chain reaction （PCR） method was adopted to respectively measure the content of serum hepatitis B virus DNA （HBV-DNA）. RESULTS The logarithm of the absolute value of the mild, moderate and severe serum HBV-DNA content were （5. 3 ± 1. 8） （6. 2± 1. 3） and （6. 7 ± 1. 5）, respectively, the difference was not statistically significant; the difference in the HBV-DNA content of alanine aminotransferase （ALT）, glutamic acid aminotransferase enzyme （AST） and total serum bilirubin （TBil） level was not statistically significant. CONCLUSION There is no significant correlation betweer; different types of chronic hepatitis B liver damage and serum HBV-DNA gene content.

关 键 词：慢性乙型肝炎 乙型肝炎病毒DNA 聚合酶链反应 

分 类 号：R512.62[医药卫生—内科学]