幽门螺杆菌cagA、vacA基因型及分子流行病学研究新进展  

Recent Advances in Molecular Genotype and Epidemiology of Helicobacter Pylori Virulence Gene cagA and vacA

作　　者：徐凯[1] 佘菲菲[1] 

机构地区：[1]福建医科大学,福建福州350000

出　　处：《中外医学研究》2012年第22期152-153,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：幽门螺杆菌是引起慢性胃炎、消化性溃疡、MALT及胃癌相关的最重要的病原体。关于幽门螺杆菌的致病机制一直以来是研究的热点,幽门螺杆菌的毒力基因对疾病的转归具有重要的影响。本文对近年来关于幽门螺杆菌最主要的两个毒力基因cagA和vacA的分子分型和流行病学调查作一综述,以对其致病机制有更加系统深入的认识。Helicobacter pylori is the most important pathogen which is involved in chronic gastritis, peptic ulcer, MALT and gastric cancer.The most research these years is focus on the relationship between H.pylori and clinical diseases.The virulence genes play a crucial role on its prediction severe diseases. This article is based on the aim to summarize the molecular genotypes and epidemiological characteristics to get a systematic and comprehensive insight of the mechanism.

关 键 词：幽门螺杆菌 毒力基因 基因型 

分 类 号：R181.3[医药卫生—流行病学] R57[医药卫生—公共卫生与预防医学]