茶碱缓释片药代动力学及临床疗效观察  

The Pharmacokenetics and Observation of Clinical Therapeutic Efficiency of Theophylline Sustained Release Tablets

作　　者：成立珠[1] 薛福林[1] 林友华[1] 范绍军 顾健 

机构地区：[1]中日友好医院

出　　处：《北京医学》1989年第5期278-280,共3页Beijing Medical Journal

摘　　要：本文对支气管哮喘、喘息型支气管炎患者共43例日服茶碱缓释片后,用紫外分光光度计测定血药浓度的变化及某些药代动力学参数。其中4例经测定半衰期为16.86±2.16小时,表现分布容积为28.37±2.58 L,血药峰值为5.74±0.27μg/ml,达峰时间为4.74±0.41小时,血药浓度曲线表现峰型平坦,有效浓度维持时间长。临床症状与肺功能得到改善,尤其是对控制夜间发作效果较好。对应用茶碱类药物患者,进行血药浓度及药代动力学测定临床上是重要的。Forty three cases of patients with bronchial asthma and asthmatic bronchitis who had received theophylline in sustained release tablets were evaluated for theophylline serum concentration and pharmacokinetics by means of ultraviolet light spectrometer methods. The study showed that the half life of the theophylline was 15.86 hours (+/-2.16). The volume of apparent distribution was 28.37 L(+/-2.58). The maximal concentration was 5.74 micrograms/ml (+/-0.27). The time of maximal blood level was at 4.74 hours (+/-0.41). The curve of the serum concentration was flat at the peak and the effective serum concentration was maintained. The clinical symptoms of the eases treated were relieved and pulmonary function was improved. The sustained release form of medication delivery was especially effective in controlling night time attacks. The authors emphasize the importance of serum testing for theophylline levels in patients during the perods of treatment for asthma.

关 键 词：氨茶碱 药代动力学 疗效 缓释片 

分 类 号：R969.1[医药卫生—药理学]