Aluminum chloride:A highly efficient catalyst for addition of amines to carbodiimides to synthesize substituted guanidines  

作　　者：ZHU XueHua XU Fan SHEN Qi 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,Chemical Engineering and Materials Science,Dushu Lake Campus,Sooehow University,Suzhou 215123,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032 China

出　　处：《Chinese Science Bulletin》2012年第26期3419-3422,共4页

基　　金：supported by the National Natural Science Foundation of China (20972107,20872106);the Department of National Education PhD Foundation;the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：A catalytic addition of amine N H bonds to carbodiimides using aluminum chloride as a Lewis acid catalyst is developed.The reaction proceeds under mild conditions without solvent to afford a series of substituted guanidines in good to excellent yields using a wide range of amines as substrates.Evidence of the proposed mechanism is provided by in situ infrared spectroscopy.A catalytic addition of amine N-H bonds to carbodiimides using aluminum chloride as a Lewis acid catalyst is developed. The reaction proceeds under mild conditions without solvent to afford a series of substituted guanidines in good to excellent yields using a wide range of amines as substrates. Evidence of the proposed mechanism is provided by in situ infrared spectroscopy.

关 键 词：碳化二亚胺 三氯化铝 高效催化剂 路易斯酸催化剂 合成 原位红外光谱 胍 催化加成 

分 类 号：O621.36[理学—有机化学]