MiRNA与皮肤伤口愈合  

MicroRNA in Cutaneous Wound Healing

作　　者：杨涛[1] 孙慧勤[1] 邹仲敏[2] 粟永萍[1] 

机构地区：[1]第三军医大学复合伤研究所 [2]第三军医大学预防医学院防化教研室,重庆400038

出　　处：《现代生物医学进展》2012年第20期3985-3987,共3页Progress in Modern Biomedicine

基　　金：国家863计划军口部分(2009AA8030423A);国家自然科学基金(31171118)

摘　　要：MiRNA是真核生物体内约由22个核苷酸组成的内源性非编码单链RNA,可调节基因转录。它通过其5'非翻译区(UTR)与目标mRNA的3'端非翻译区相结合,从而抑制后者的转录后翻译和降解,进而调节一系列生物学过程,包括生物体生长、发育和疾病等。研究表明,miRNA在干细胞分化、肿瘤形成、血管发生、内耳形成等过程中均发挥重要作用,已成为调节生物学过程的核心因子。伤口愈合是一个与多种类型细胞、细胞因子及细胞外基质相关的过程,它受机体多种因素紧密调控。伤口愈合过程一般被分为三个阶段:炎症反应期,肉芽生长期和组织重建期。已有大量证据证实miRNA在皮肤创伤愈合过程中发挥重要作用,并且miRNA在不同的愈合阶段发挥不同的作用。本文就miRNA在皮肤形态、胎儿无痕愈合及成人伤口愈合各环节中的作用做一综述。MiRNAs are ～22-nucleotide-long endogenously expressed non-coding single-strain RNAs that regulate the gene transcription.They could modulate the growth,development and diseases of organism by inhibition of post-transcriptional translation and degradation of mRNA,through binding its 5’ UTR to 3’UTR of mRNA.It has been proposed that miRNAs play a significant role in differentiation of stem cells,formation of cancer,angiogenesis,development of inner ear,and so on,which has been a core factor of regulation of biological processes.Cutaneous wound healing is a complex biologic process involved in several type of cells,cytokines and extracellular matrix,which is strictly regulated by lots of factors.It has been divided into 3 phases： inflammation,granulation proliferation and tissue reconstruction.A large number of evidence suggested that miRNAs play a significant role in this process,and specific miRNAs are expressed in specific phases.This article reviews the role of miRNA in skin morphogenesis,fetal scarless healing and different stage of adult wound repair.

关 键 词：MIRNA 皮肤伤口愈合 

分 类 号：R641[医药卫生—外科学]