艾滋病治疗药物—HIV抑制剂作用机制及研究进展  

Anti-AIDS drugs——HIV Inhibitors: Function Mechanism and Research Progress

作　　者：杨文思[1] 王洋[2] 

机构地区：[1]河北大学生命科学学院,河北保定071000 [2]河北联合大学,河北唐山063000

出　　处：《现代生物医学进展》2012年第23期4560-4562,4565,共4页Progress in Modern Biomedicine

摘　　要：艾滋病(AIDS)是由人类免疫缺陷病毒(HIV)感染而引起的慢性进行性致死性传染病,又称获得性免疫缺陷综合症,目前无有效治愈的方法,严重危害着人类的健康。现今,艾滋病治疗药物主要包括逆转录酶抑制剂、蛋白酶抑制剂、进入抑制剂、整合酶抑制剂四大类化学药物和一些中草药制剂。抗HIV药物虽然不能完全治愈艾滋病,但可以控制艾滋病病情的发展,延长患者的无病生存期,提高患者的生活质量。本文就艾滋病发病机制、HIV抑制药物的抗病机制、副作用及其研究进展做一综述。AIDS or Acquired Immune Deficiency Syndrome is a progressive and fatal contagious disease caused by human immunodeficiency virus （HIV）. Currently, as an incurable disease, AIDS became a serious public health problem in the whole world. At present, anti-AIDS drugs are mainly belong to HIV inhibitors, including inhibitors of reverse transeriptase, protease, integrase and entry inhibitors, as well as some Chinese herbal medicines. Although these anti-HIV drugs can not cure AIDS, it may enhance patient＇s life quality and prolong disease free survival. This article will review the function mechanism, by-effect and research progress of H1V inhibitors.

关 键 词：艾滋病 HIV HIV抑制剂 

分 类 号：R512.91[医药卫生—内科学]