BIS在氯胺酮联合咪达唑仑小儿麻醉深度中的监测价值评价  

Evaluation on monitoring value of bispectral index in pediatric anesthesia depth of ketamine combined with midazolam

作　　者：蔡军[1,2] 周成华[1] 周策[1] 陆富钊[1] 李鑫[1] 黄鹂[1] 李伟[1] 张永 陈虎[4] 武玉清[1] 

机构地区：[1]徐州医学院江苏省麻醉学重点实验室,江苏徐州221004 [2]连云港市妇幼保健院麻醉科,江苏连云港222006 [3]徐州市第六人民医院泌尿外科,江苏徐州221006 [4]泗洪县人民医院普外科,江苏泗洪223800

出　　处：《徐州医学院学报》2012年第7期421-423,共3页Acta Academiae Medicinae Xuzhou

基　　金：国家自然科学基金（81070889、81171013）;江苏省高校自然科学重大基础研究项目（10KJA320052）;江苏高校优势学科建设工程资助项目

摘　　要：目的探讨脑电双频指数（bispectralindex，BIS）在氯胺酮联合咪达唑仑进行小儿腹股沟斜疝手术麻醉深度监测中的应用价值。方法选择择期行腹股沟斜疝手术的患儿40例，年龄2～6岁，ASAⅠ～Ⅱ级，随机分成BIS监测组（B组）和对照组（C组）。B组（20例）通过术中监测BIS数值，调整氯胺酮和咪达唑仑剂量使其维持在78±5；C组根据术中患儿的血流动力学反应、呼吸频率改变和出现体动反应来调整氯胺酮和咪达唑仑用量大小。结果同C组相比，B组患儿镇静充分，血流动力学波动较小，术后苏醒时间缩短，有统计学意义（P〈0．05）。结论应用BIS能连续、客观地监测并控制氯胺酮联合咪达唑仑进行小儿腹股沟斜疝手术的麻醉深度，缩短术后苏醒时间，有利于术中镇静及增强患儿的舒适感和安全性。Objective To evaluate the value of bispeetral index （BIS） monitor in pedo - oblique inguinal hernia operation through anesthesia by ketamine combined with midazolam. Methods Forty 2 - to 6 - year - old child patients undergoing pedo - oblique inguinal hernia surgery in 2011 were randomly divided into 2 groups ： BIS group （ B, n = 20 ） and control group （ C, n = 20）. In group B, we controlled the dosage of ketamine and midazolam by BIS monitor （78 ＋_ 5 ）. In group C, we controlled the dosage of ketamine and midazolam by observation of haemodynamie reaction, respirato- ry rate and boby movement. Results Compared to group C, there is less haemodynamie fluetuation and shorter analepsia time and better sedation in group B. Conclusion BIS monitor could control the depth of anesthesia, shorten analepsia time by continuous and objective monitoring in pedo - oblique inguinal hernia operation, which results in better sedation in surgery and enhaneernentof pedo - patient comfort and safety.

关 键 词：脑电双频指数 氯胺酮 咪达唑仑 儿童 麻醉 

分 类 号：R614.2[医药卫生—麻醉学]