不同剂量奥美沙坦对原发性高血压患者血压及胰岛素抵抗的影响  

Effect of olmesartan on blood pressure and insulin resistance in essential hypertensive patients

作　　者：高瑜[1] 张佩生[1] 梁雪[1] 

机构地区：[1]郑州大学第五附属医院心内二科,郑州450052

出　　处：《中国实用医药》2012年第20期4-5,共2页China Practical Medicine

摘　　要：目的研究不同剂量奥美沙坦对原发性高血压(Essential hypertension,EH)患者血压及胰岛素抵抗(insulin resistance,IR)的影响。方法 EH患者65例随机分成A组(奥美沙坦20mg)33例,B组(奥美沙坦40mg)32例,治疗12周。观察两组治疗前后的动态血压(ABPM)、空腹血糖(FPG)和胰岛素(FINS)、胰岛素敏感指数(ISI)和胰岛素抵抗指数(HOMA-IR)水平的变化。结果①治疗后两组EH患者血压水平均较治疗前明显降低,B组较A组更为明显,差异有统计学意义(P<0.05)。②治疗后两组ISI均明显高于治疗前,B组升高更为明显,差异有统计学意义(P<0.05);治疗后两组HOMA-IR均明显低于治疗前,B组降低更为明显,差异有统计学意义(P<0.05)。结论奥美沙坦可有效降压及改善胰岛素抵抗,且存在剂量相关性。Objective To investgate the effect of olmesartan on blood pressure and insulin resistance in essential hypertensive patients. Methods Sixty-five essential hypertensive patients were randomly divided into two groups： A group（ olmesartan 20 rag） and B group （olmesartan 40 rag）, to follow up for twelve weeks. Ambulatory blood pressure monitorin （ABPM） and fasting plasma glucose and insulin （FINS）, insulin sensitivity index （ISI） and homoeostasis model assessment of insulin resistance （HOMA-IR）were compared between two groups. Results ①After treatment, blood pressure of two groups were significantly lower than before, it was more obvious in B group, the difference was statistically significant （P 〈 0. 05） . ②In two groups after the treatment, ISI were higher than those before treatment, it was more obvious in B group, the difference was statistically significant （P 〈 0. 05） ; in two groups after the treatment, HOMA-IR were significantly lower than those before treatment, it was more obvious in B group, the difference was statistically significant （P 〈0. 05）. Conclusion Olmesartan has effect on antihypertensive therapy and improving insulin resistance, and there is a dose dependency.

关 键 词：高血压 奥美沙坦 胰岛素抵抗 

分 类 号：R544.1[医药卫生—心血管疾病]