17例妊娠期急性脂肪肝的临床分析  

Clinical analysis on 17 cases with acute fatty liver of pregnancy

作　　者：王艳玲[1] 

机构地区：[1]安徽医科大学第一附属医院妇产科,安徽合肥230022

出　　处：《中国妇幼保健》2012年第24期3720-3722,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨妊娠期急性脂肪肝(AFLP)的临床特点、诊治方法及母儿预后。方法:对2006年4月～2011年12月安徽医科大学第一附属医院收治的17例AFLP患者的症状、实验室检查、临床过程及母亲和围产儿结局进行回顾性分析。结果:17例患者首发症状均为消化道症状,短期内可出现不同程度的肝肾功能损伤及凝血功能改变,严重时发生弥漫性血管内凝血及多脏器功能衰竭。结论:AFLP患者的预后与新生儿预后、病程长短及治疗密切相关;对AFLP患者进行早期诊断及治疗,及时终止妊娠,积极预防DIC,补充凝血物质,有利于改善AFLP患者及围产儿预后。Objective：To explore the clinical characteristics,diagnosis,treatment,and maternal and infantile prognosis of cases with acute fatty liver of pregnancy（AFLP）.Methods：The symptoms,laboratory examination,maternal and perinatal outcomes of 17 cases with AFLP who were treated in the hospital from April 2006 to December 2011 were analyzed retrospectively.Results：The initial symptoms of all the 17 cases with AFLP were gastrointestinal symptoms;hepatic injury,renal injury,and changes of coagulation function of different degrees occurred in a short time,disseminated intravascular coagulation（DIC） and multiple organ failure occurred when the disease was serious.Conclusion：The prognosis of the cases with AFLP was correlated with neonatal prognosis,the course of disease,and therapy closely;early diagnosis and treatment should be performed among the cases with AFLP;terminating pregnancy timely,preventing DIC actively,and supplying prothrombin are helpful to improve prognosis of the cases with AFLP and perinatal infants.

关 键 词：妊娠期急性脂肪肝 肝功能衰竭 弥漫性血管内凝血 

分 类 号：R714.255[医药卫生—妇产科学]