青礞石的炮制工艺研究  

Studies on processing technology of Chloriti Lapis

作　　者：刘圣金[1] 吴德康[1] 林瑞超[2] 刘训红[1] 傅兴圣[1] 段金廒[1] 孔庆友[3] 

机构地区：[1]南京中医药大学,江苏南京210046 [2]中国药品生物制品检定所,北京100050 [3]南京大学,江苏南京210093

出　　处：《中草药》2012年第8期1508-1513,共6页Chinese Traditional and Herbal Drugs

基　　金：国家"十一五"科技支撑计划项目(2006BAI55B02);江苏省普通高校研究生创新计划项目(CX09B-282Z);江苏省名老中医药专家师承项目(2009);南京中医药大学中药学一级学科开放课题资助项目(2011ZYX1-002)

摘　　要：目的优选青礞石的炮制工艺参数,为控制青礞石炮制品质量及其安全性奠定基础。方法通过多项指标评价,首先筛选出是否需用火硝进行炮制;再采用L9(34)正交优选法,以青礞石炮制品的外观颜色、疏松度、溶出率等筛选炮制工艺参数。结果最佳炮制工艺为在700℃、青礞石与火硝质量配比1∶0.4、摊层厚度2 cm条件下煅制2 h。结论该工艺条件稳定、合理、可行,为矿物类中药的炮制工艺提供了研究思路与方法。Objective To optimize the processing parameters and lay the fundation for the quality control and safety of ChloritiLapis. Methods Evaluated by a number of indexes, whether potassium nitrate was needed in processing was decided. And then using surface color, bulk density, and water dissolution rate to optimize the optimized processing parameters of Chloriti Lapis by L9（3^4） orthogonal test. Results The optimum processing technology was the weight ratio of Chloriti Lapis-nitre at 1 ： 0.4, thickness of layer-share with 2 cm, at temperature 700℃, and processed for 2 h. Conclusion The processing technology is stable, reasonable, and feasible, and provides the research thinking and method for processing technology of mineral Chinese medicine.

关 键 词：矿物药 青礞石 炮制工艺 热分析 X射线衍射 火硝 

分 类 号：R283.1[医药卫生—中药学]