清宫胶囊治疗药物流产后出血患者49例临床观察  

Clinical Observation on Qinggong Capsule for 49 Cases of Hemorrhage after Drug-induced Abortion

作　　者：李艳青[1] 陈顺强[2] 孙红[1] 

机构地区：[1]河南省中医院妇科 [2]河南省人民医院

出　　处：《中医杂志》2012年第16期1387-1389,1393,共4页Journal of Traditional Chinese Medicine

基　　金：河南省科技发展计划资助项目(0224630004)

摘　　要：目的观察中药清宫胶囊治疗药物流产后出血的临床疗效。方法将97例药物流产后出血患者随机分为治疗组49例和对照组48例。两组均采用口服药物流产,服药后第7天治疗组口服清宫胶囊,每次4粒,每日3次;对照组口服益母草胶囊,每次4粒,每日3次。5天为1个疗程,用药不超过3个疗程。两组分别于就诊当天(治疗前)、治疗后第5、10、18天检测血人绒毛膜促性腺激素β亚基(β-HCG)、雌二醇(E2)、孕酮(P)水平,并观察药物流产后出血时间及转经情况。结果治疗组49例中治愈25例(51.02%),有效22例(44.90%),无效2例(4.08%);对照组48例中治愈18例(37.50%),有效19例(39.58%),无效11例(22.92%),两组比较差异有统计学意义(P<0.05)。治疗组药物流产后平均出血时间短于对照组(P<0.01)。治疗组在9天内出血停止的例数明显多于对照组(P<0.01)。治疗组转经周期、转经经期均短于对照组(P<0.05或P<0.01)。两组治疗后5、10、18天β-HCG、E2、P水平与治疗前比较差异均有统计学意义(P<0.05或P<0.01)。治疗后5、10、18天两组间β-HCG比较差异有统计学意义(P<0.05)。结论清宫胶囊可有效缩短药物流产患者出血时间及月经恢复时间,减少出血量,其作用与加强子宫收缩,减少体内β-HCG分泌,促进子宫内膜修复有关。Objective To observe the therapeutic effect of Qinggong Capsule （capsule to repair uterine） on hemorrhage after drug-induced abortion. Methods Nighty seven patients with hemorrhage after drug-induced abortion were randomized into treatment group of 49 cases and control group of 48 cases. Both groups were givefa mifepristone and misoprostol to induce abortion, in addition, the treatment group and control group was given Qinggong Capsule and Leonurus Capsule respectively on the 7th day, 4 capsules once, three times daily. One treatment course lasted for 5 days. The medication was not more than three courses in both groups. Beta-human chorionic gonadotropin （β-HCG）, estradiol （E2 ）, progesterone （P） were observed on the 1st, 5th, 10th, 18th day, and bleeding time and menstrual recovery were observed after treatment. Results Of 49 cases in the treatment group, there were 25 cases （51.02%） cured, 22 cases （44.90%） effective, and 2 cases （4.08%） ineffective. And of the 48 cases in the control group, there were 18 cases （37.50%） cured, 19 cases （39.58%） effective, and 11 cases （22.92%） ineffective. The difference between groups was statistically significant （P〈0.05）. The average bleeding time was （10.38 ± 0.36） and （13. 54±0.56） days in the treatment group and control group respectively, with significant difference between groups （P〈0.01）. The cases of bleeding stopped within 9 days in the treatment group were much more than those in the con- trol group （P〈0.01）. The period of menstrual recovery was （30.5±5.2） and （33.8±8.6） days and the menstrual duration was （6.1± 3.5） and （9.9± 5.1） days in the treatment group and control group respectively. The time of menstrual recovery and menstrual duration in the treatment group were shorter than those in the control group （P〈0.05 or P〈0.01）. On the 5th, 10th and 18th day of treatment, there were significant differences in β-HCG, E2 and P in both groups as compared with those before

关 键 词：清宫胶囊 药物流产 子宫出血 内分泌 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]