中孕引产中胎盘粘连者胎盘血管生成素1,2的表达  

Expressions of angiopoietin 1 and 2 in the placenta of women with placenta adherence during induced abortion in the mid-trimester of pregnancy

作　　者：曾成英[1] 郭遂群[1] 耿蔷[1] 魏清柱[2] 肖小敏[3] 

机构地区：[1]南方医科大学第三附属医院妇产科,广州市510630 [2]南方医科大学第三附属医院病理科,广州市510630 [3]暨南大学医学院附属第一医院妇产科,广州市510632

出　　处：《实用医学杂志》2012年第16期2715-2717,共3页The Journal of Practical Medicine

基　　金：广东省人口和计划生育委员会立项(编号:20100334)

摘　　要：目的:探讨中孕引产后胎盘粘连与胎盘血管生成素1(Ang-1)和血管生成素2(Ang-2)表达的关系。方法:孕13～24周来我院要求终止妊娠的孕妇中,入院后按知情同意的原则选择利凡诺引产及水囊引产的61例分为两组,A组:利凡诺组40例;B组:水囊组21例,采用免疫组化方法检测胎盘中Ang-1和Ang-2的表达情况,比较胎盘Ang-1、Ang-2与胎盘粘连的关系。结果:A组与B组的胎盘粘连发生率分别为50%及47.62%,两者间差异无显著性(P>0.05);两组中胎盘粘连者Ang-1的表达均高于无粘连者,Ang-2的表达粘连者低于无胎盘粘连者,差异有显著性(P﹤0.05)。结论:中孕引产后胎盘粘连可能与胎盘Ang-1的表达增强、Ang-2的表达减弱有关,可能与Ang-1/Ang-2的比率改变有关。Objective To investigate the relation of placenta adherence with the expressions of angiopoietin-1 （Ang-1） and Ang-2 in placenta in the mid trimester of pregnancy. Methods 61 women with 13-24 weeks of gestation who wanted to terminate pregnancy in our hospital were divided into 2 groups： Group A received the induced abortion with intra-amniotic injection of rivanol （n = 40） and Group B received cystic method （n = 21 ）. The expressions of Ang-1 and Ang-2 were assayed by immunohistochemical staining, then the relation of expression of placenta adherence with the expressions of Ang-1 and Ang-2 was analyzed. Results The rates of placenta adherence were 50% and 47.26% in Group A and B （P 〉 0.05）. The expression of Ang-1 was higher in women with placenta adherence than those without （P 〈 0.05）, while the expression of Ang-2 was on the contrary （P 〈 0.05）. Conclusions The placenta adherence after induced abortion in mid-trimester of pregnancy may be related to the higher expression of Ang-1, the lower expression of Ang-2, and the change of Ang-1/Ang-2 ratio.

关 键 词：中孕引产 胎盘粘连 血管生成素-1 血管生成素-2 

分 类 号：R719.3[医药卫生—妇产科学]