含笼形POSS的PNIPAM温敏性水凝胶的溶胀及药物缓释行为  

Swelling Behaviors and Drug Release Property of Poly(N-Isopropylacrylamide)Thermosensitive Hydrogels Containing Cage-Like Polyhedral Oligomeric Silsesquioxane

作　　者：张晓静[1] 孙家书[1] 韩喜妞[1] 王超君[1] 李亚东[1] 方少明[1] 

机构地区：[1]郑州轻工业学院材料与化学工程学院,河南省表界面科学重点实验室,河南郑州450002

出　　处：《高分子材料科学与工程》2012年第8期76-80,共5页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(20804041);河南省教育厅自然科学基金资助项目(2009A430025);河南省高校科技创新团队支持计划(2008IRTSTHN004)

摘　　要：以八乙烯基低聚倍半硅氧烷(OVPS)为交联剂,通过溶液共聚制备了聚N-异丙基丙烯酰胺有机/无机杂化水凝胶(P(OVPS-co-NIPAM)),研究了其溶胀、消溶胀和再溶胀及药物缓释行为。结果表明,所有P(OVPS-co-NIPAM)杂化水凝胶的平衡溶胀率SR均随温度升高而降低。20℃,5-P(OVPS-co-NIPAM)杂化水凝胶在去离子水中的SR与常规水凝胶P(MBA-co-NIPAM)相同,但在生理盐水中的SR,前者明显大于后者。随着OVPS含量的增加,杂化水凝胶的SR、再溶胀和消溶胀速率均逐渐下降。5-P(OVPS-co-NIPAM)杂化水凝胶的载药率和累积释药率均高于常规水凝胶P(MBA-co-NIPAM)。此外,P(OVPS-co-NIPAM)杂化水凝胶的药物释放速率均高于常规水凝胶,而且20℃时随OVPS含量增加,释药加快。A series of organic-inorganic hybrid hydrogels（P（OVPS-co-NIPAM）） based on（N-isopropylacrylamide）（NIPAM） using octavinyl polyhedral oligomeric silsesquioxane（OVPS） as the crosslinker were synthesized by solution free radical copolymerization.The influence of OVPS content on the swelling,deswelling and reswelling behaviors in deionized water and normal saline,as well as the drug release behavior with norfloxacin as the model drug were investigated.The results show that the equilibrium swelling ratio（SR） of all P（OVPOSS-co-NIPAM） hydrogels exhibits temperature dependence.The SR of 5-P（OVPS-co-NIPAM） hybrid hydrogel in water at 20 ℃ is basically same with that of the traditional hydrogel using N,N′-methylenebisacrylamide（MBA） as the crosslinker（P（MBA-co-NIPAM））,while the SR of the former in normal saline is larger than that of the latter.The SR and the rates of deswelling and reswelling of P（OVPS-co-NIPAM） hydrogels decrease when the OVPS content increasing.The drug release on norfloxacin reveals that 5-P（OVPS-co-NIPAM） hydrogel possesses higher drug loading ratio and cumulative drug release ratio than P（MBA-co-NIPAM）.Furthermore,the drug release rates of all the P（OVPS-co-NIPAM） hydrogels are also higher than that of P（MBA-co-NIPAM） and increase with the OVPS contents increasing at 20 ℃.

关 键 词：多面体低聚倍半硅氧烷 聚N-异丙基丙烯酰胺 杂化水凝胶 溶胀 药物缓释 

分 类 号：TQ427.25[化学工程]