复合壳层聚合物胶束的药物控制释放  

Controlled Release for Drug of Complex-Shell Block Copolymer Micelles

作　　者：张晓晖[1] 赵书义[1] 马敬红[1] 杨曙光[1] 龚静华[1] 

机构地区：[1]东华大学纤维材料改性国家重点实验室,上海201620

出　　处：《高分子材料科学与工程》2012年第8期125-128,共4页Polymer Materials Science & Engineering

摘　　要：通过连续原子转移自由基聚合(ATRP)合成了聚丙烯酸叔丁酯-b-聚(甲基丙烯酸二甲胺基乙酯)(PtBA-b-PDMAEMA)和聚丙烯酸叔丁酯-b-聚异丙基丙烯酰胺(PtBA-b-PNIPAM),并采用选择性溶剂自组装方法制备了具有复合壳层的核壳结构胶束(Dh=209 nm),采用动态光散射及透射电镜研究了胶束的结构和分布,进一步通过紫外光谱对胶束的药物释放性能进行了表征。研究表明,这种复合壳层的聚合物胶束会在壳层形成可控的药物通道,从而实现药物释放的精确控制。Poly（t-butyl acrylate）-b-poly（2-dimethylamino）ethyl methacrylate（PtBA-b-PDMAEMA） and poly（t-butyl acrylate）-b-poly（n-isopropyl acrylamide）（PtBA-b-PNIPAM） were synthesized by sequential atom transfer radical polymrization（ATRP）.Then micelles with complex-shell structure were formed in selective solvent by self-assemble.The hydrodynamic radius（Rh） and size-distribution of the micelles were studied in detail via dynamic light scattering（DLS） and transmission electron microscope（TEM）.The controlled release of drug from the complex-shell micelles was characterized by ultraviolet spectrum（UV）.The results indicate that the controllable drug channels could be formed in the shell of the micelles,which realize the accurate control of the drug release.

关 键 词：原子转移自由基聚合 自组装 复合胶束 药物释放 

分 类 号：TQ316.62[化学工程—高聚物工业]