强酸性离子交换树脂催化合成2-正丙基-4,7-二氢-1,3-二氧七环  

Preparation of 4,7-dihydro-2-n-propyl-1,3-dioxetpin catalyzed by strong acidic cation exchange resin

作　　者：章根宝 徐勇智 范卫东 党登峰 洪丰庆 

机构地区：[1]浙江天新药业有限公司,浙江台州317200

出　　处：《应用化工》2012年第8期1372-1374,共3页Applied Chemical Industry

基　　金：浙江省重大科技专项(2010C11034)

摘　　要：采用强酸性离子交换树脂、环己烷分别替代传统的催化剂硫酸及带水剂苯,以2-丁烯-1,4-二醇和正丁醛为原料,制备了2-正丙基-4,7-二氢-1,3-二氧七环,研究了收率的各种影响因素。改进后的工艺革除了高毒性苯,正丁醛与2-丁烯-1,4-二醇最佳投料比为1.2∶1(摩尔比),收率达95%以上,催化剂可循环使用5次。本工艺后处理简单,适于工业化应用。In stead of traditional sulfuric acid catalyst and benzene as water-carrying agent, strongly acidic ion exchange resin and cyclohexane were applied to the preparation of 4,7-dihydro-2-n-propyl-1,3-dioxet- pin from 2-butane-1,4-diol and butyraldehyde, and the factors affecting the yield were studied. After high toxic benzene removed, the optimum molar ratio of butyraldehyde to 2-butane-1,4-diol is 1.2 ： 1, the yield is above 95% ,and the catalyst can be recycled 5 times. The post treatment of this process is simple, so it is suitable for industrial application.

关 键 词：维生素B6 共沸脱水 强酸性离子交换树脂 缩醛化 

分 类 号：TQ463.5[化学工程—制药化工]