论无创血糖监测的红外光谱方法(特邀)  

Infrared spectroscopy for non-invasive blood glucose monitoring(Invited)

作　　者：陈星旦[1] 高静[1,2] 丁海泉[1] 

机构地区：[1]中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室,吉林长春130033 [2]中国科学院研究生院,北京100049

出　　处：《中国光学》2012年第4期317-326,共10页Chinese Optics

基　　金：国家自然科学基金资助项目(No.60938002);中国科学院知识创新工程领域前沿资助项目(No.Y00232Q100);应用光学国家重点实验室开放课题资助项目(No.Y1Q03FQ113)

摘　　要：介绍了无创血糖监测的几种光学方法以及红外光谱法用于无创血糖监测的优势。分析了无创血糖监测红外光谱法的主要问题,包括光在人体组织中的复杂传播;葡萄糖吸收信号微弱,且与人体中其它生化成分吸收光谱重叠;人体组织背景吸收干扰严重等。总结了无创血糖监测红外光谱法的最新进展,给出抑制人体组织背景吸收干扰的方法,并认为组织液可代替血液用于血糖水平的测量。展望了该领域未来研究趋势,主要涉及精确描述光子在组织中的传输、测量皮肤表皮内或表皮与真皮浅层光谱信息,以及提高光谱仪器信噪比,建立葡萄糖吸收带定标模型。Some optical methods for non-invasive blood glucose monitoring are introduced,and the advantages of infrared spectroscopy applied to the non-invasive blood glucose monitoring are presented.The main problems of infrared spectroscopy in the non-invasive blood glucose monitoring are analyzed,including complicated transmission of light in tissue,weak absorption signal of glucose,overlapped absorption spectra of different biochemistry components,serious interference of background absorption and so on.Recent advances of infrared spectroscopy in non-invasive blood glucose monitoring are summarized and the methods to restrain the interference of background absorption are pointed out.It suggests that the tissue fluid can replace the blood applied to the measurement of blood glucose.Finally,the paper gives further research trends of this field,which includes describing the transmission of light in tissue accurately,measuring the spectra of epidermis or the superficial layer between epidermis and dermis,improving instrument SNR,and building the calibration model for the absorption band of blood glucose.

关 键 词：红外光谱 无创监测 血糖监测 光谱分析 

分 类 号：O657.33[理学—分析化学] O433.4[理学—化学]