间充质干细胞治疗3例难治性慢性苯中毒病例探索  

Preliminary research on mesenchymal stem cells in treatment for refractory chronic benzene poisoning

作　　者：黄明[1] 夏丽华[1] 郎丽[1] 李力[2] 黄汉林[1] 庞妍[2] 陈嘉斌[1] 

机构地区：[1]广东省职业病防治院,广东广州510300 [2]广州军区广州总医院,510010

出　　处：《中国职业医学》2012年第4期282-284,共3页China Occupational Medicine

基　　金：广东省医学科学研究资助项目(A2012063);广东省职业病防治院专项课题(Z200907)

摘　　要：目的观察间充质干细胞(MSC)对难治性慢性苯中毒是否存在治疗价值。方法以3例难治性慢性苯中毒患者为研究对象,将健康供者的MSC进行分离培养、扩增,再输注给患者,监测患者的白细胞、中性粒细胞、血红蛋白、血小板和不良反应等临床指征,进行临床评估。结果 3例难治性慢性苯中毒患者均有不同程度的疗效,其中1例达到临床治愈,且未出现明显不良反应。结论 MSC对难治性慢性苯中毒有潜在治疗价值。Objective To evaluate treatment value of mesenchymal stem cell （MSC） on refractory chronic benzene poison- ing. Methods 3 cases of refractory chronic benzene poisoning were selected as the research objects, MSC from healthy donors were cultured, proliferated and then transplanted to patients. Clinic guidelines such as WBC, neutrophils, Hb, Pit and adverse reaction were observed. Results 3 refractory chronic benzene poisoning patients had all acquired curative effect with different degrees, one had even acquired clinically cured. No significant side effects or toxic reactions were found. Conclusion It is con- cluded that MSC has potential therapeutic value on refractory chronic benzene poisoning.

关 键 词：间充质干细胞 慢性 苯中毒 难治性 治疗 

分 类 号：R135.12[医药卫生—劳动卫生]