从证候分子本质论食管癌血瘀病机  

Discussion on Pathogenesis on Blood Stagnation of Esophageal Carcinoma from Molecular Essence of Syndrome

作　　者：贾永森[1] 李继安[1] 韩炳生[2] 

机构地区：[1]河北联合大学中医学院,河北唐山063000 [2]深圳市中医院,广东深圳518020

出　　处：《辽宁中医杂志》2012年第8期1504-1505,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：深圳市科技研发资金项目(ZYA201007060089A);河北联合大学博士科研启动基金(BS09034);河北联合大学青年科学基金(QK03212010);唐山市科学技术研究与发展计划课题(11150205A-7)

摘　　要：瘀血体质、体内血瘀不祛,是食管癌发生的重要内环境。通过总结古代医家有关食管癌血瘀病机的认识,结合基础实验研究,并利用方证关系理论,文章对食管癌血瘀病机的分子本质进行了分析讨论,以确定血瘀病机的证候分子标志物。EGFR、PI3K/AKT和Caspase-3信号通路蛋白表达的异常与血瘀病机密切相关,可以为食管癌的瘀血证分子诊断提供参考。Constitution of blood stasis and generation of stagnation are important internal circumstances for esophageal cancer.Through summary on literatures of blood-stasis pathogenesis on esophageal cancer in ancient China,combined with experiments results,discussion on molecular essence of stagnation syndrome is investigated with theory of relations between syndrome and formula.Molecular markers for blood-stasis are located,including EGFR,several key proteins in signal pathways mediated by PI3K/AKT and Caspase-3.The results may provide reference for diagnosis on esophageal cancer.

关 键 词：食管癌 血瘀 分子 证候 

分 类 号：E735.1[军事—军事理论]