姜黄素对支气管哮喘大鼠气道重塑和核因子-κB的影响  

Effects of Curcumin on Airway Remodeling and Nuclear Factor Kappa-B in Asthmas Rats

作　　者：王三萍[1] 雷晓燕[1] 熊海金[1] 王景萍[1] 杨丽[1] 

机构地区：[1]甘肃省人民医院儿科,甘肃兰州730000

出　　处：《上海中医药大学学报》2012年第4期92-94,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：甘肃省中医药科研基金资助项目(05-GZK-20)

摘　　要：目的:探讨姜黄素对支气管哮喘大鼠气道重塑及核因子-κB(NF-κB)的影响。方法:将Wistar大鼠随机分为对照组、哮喘组、姜黄素组,各10只;采用卵蛋白(OVA)致敏复制大鼠哮喘模型。观察3组大鼠气道炎症、气道壁厚度、胶原沉积及NF-κB和转化生长因子(TGF-β1)表达情况。结果:哮喘组大鼠炎性细胞浸润、胶原沉积、气道壁厚度、NF-κB、TGF-β1表达与对照组比较有显著性差异(P<0.01),而姜黄素组较哮喘组明显减轻(P<0.01);NF-κB与TGF-β1表达、气道炎症、气道壁厚度、胶原沉积变化成正相关(P<0.01)。结论:姜黄素可抑制哮喘大鼠NF-κB活性以干预其气道重塑。Objective： To investigate the influence of cureumin on airway remodeling and nuclear factor kappa-B（NF-kB） in rats with asthmas. Methods： Wistar rats were randomly divided into three groups： control group, asthma group and curcumin group, lO rats in each group. Asthma model was duplicated by injecting ovalbumin （ OVA ）. The airway inflammation, thickness, collagen deposit, NF-kB and transformation growth factor betal （TGF-β1） were observed. Results： There were significant differences in airway inflammation, thickness, collagen deposit, NF-kB and TGF-β1 expressions between control group and asthma group, and between asthma group and eurcumin group（P 〈 0.01 ） ; NF-KB expression was positively correlated with TGF-β1 expression, airway inflammation, airway thickness and collagen deposition（P 〈 0.01 ）. Conclusion： Cureumin can down-regulate NF-KB expression to suppress airway remodeling in asthma tats.

关 键 词：姜黄素 支气管哮喘 气道重塑 核因子-κB(NF-κB) 转化生长因子(TGF-β1) 

分 类 号：R285.5[医药卫生—中药学]