Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells  

作　　者：郑书岩 符润中 沈征武 

机构地区：[1]School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China [2]Departmen of Applied Chemistry, East China University of Sciences and Technology, Shanghai 20000, China [3]Basilea Pharmaceutica China Ltd., Haimen, Jiangsu 226100, China

出　　处：《Chinese Journal of Chemistry》2012年第7期1405-1409,共5页中国化学（英文版）

摘　　要：We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activities of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activities of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.

关 键 词：hirtellanine B SYNTHESIS ANTIPROLIFERATION G2/M arrest cancer cell 

分 类 号：Q279[生物学—细胞生物学] Q343.245