cis-Nitenpyram Analogues Containing 1,4-Dihydropyridine： Synthesis, Insecticidal Activities, and Molecular Docking Studies  

作　　者：孙传文 陈艳霞 刘天雁 吴颖 方庭 王静 邢家华 

机构地区：[1]College of Life and Environment Sciences,Shanghai Normal University,Shanghai 200234,China [2]Bioassay Department,Branch of National Pesticide R&D South Center,Hangzhou,Zhejiang 310023,China

出　　处：《Chinese Journal of Chemistry》2012年第7期1415-1422,共8页中国化学（英文版）

基　　金：Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc.201200165.Acknowledgement This work was supported by the National Natural Science Foundation of China （21042010, 21102092 and 30870560）, the Key Scientific ＂Twelfth Five-Year＂ National Technology Support Program （2011BAE06B0117）, the Innovation Project of Shanghai Education Commission （12YZ078）, the Leading Academic Discipline Project of Shanghai Normal University （DZL808）, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University （07dz22303）. We are also grateful for the support from Branch of National Pesticide R＆D South Center.

摘　　要：A novel series of cb-nitenpyram analogues （2a--2p） were designed and prepared by introducing the 1,4-dihydropyridine, with their eis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most compounds exhibited good insecticidal activities at 20 mg/L against Aphis medicagini, and analogues 2a and 2d aflbrded the best activity, and both of them had 100% mortality at 4 mg/L. In addition, molecular docking studies were also performed to model the ligand-receptor complexes, and the results explained the structure-activity relationships observed in vitro, which may provide some useful information for future design of new insecticides.A novel series of cb-nitenpyram analogues （2a--2p） were designed and prepared by introducing the 1,4-dihydropyridine, with their eis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most compounds exhibited good insecticidal activities at 20 mg/L against Aphis medicagini, and analogues 2a and 2d aflbrded the best activity, and both of them had 100% mortality at 4 mg/L. In addition, molecular docking studies were also performed to model the ligand-receptor complexes, and the results explained the structure-activity relationships observed in vitro, which may provide some useful information for future design of new insecticides.

关 键 词：cis-nitenpyram analogue 1 4-DIHYDROPYRIDINE synthesis insecticidal acvitity molecular docking 

分 类 号：S816.7[农业科学—饲料科学] TQ453.299[农业科学—畜牧学]