BiX3 and FeX3-Promoted Prins Cyclization of Enol Ethers in CH2Cl2  

作　　者：杨艺 贾平敬 刘素平 于炜 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu 730000,China

出　　处：《Chinese Journal of Chemistry》2012年第7期1439-1444,共6页中国化学（英文版）

基　　金：Supporting information for this article is available on the WWW under http：//dx.cioi.org/10. 1002/cjoc.201100659 or from the author.Acknowledgement The authors thank the National Natural Science Foundation of China （No. 20772053） and the Fundamental Research Funds for the Central Universities forfinancial support.

摘　　要：The Prins cyclization of enol ethers has been realized by employing BiX3 （or FeX3） as catalyst and TMSX （X = Br, C1） as the halogen source. The presence of a tiny amount of water in the solvent dichloromethane played a key role for the reaction to proceed. The reaction is believed to be catalyzed by Lewis acid-assisted Bronsted acids, which were generated in situ from MX3 and water in the solvent.The Prins cyclization of enol ethers has been realized by employing BiX3 （or FeX3） as catalyst and TMSX （X = Br, C1） as the halogen source. The presence of a tiny amount of water in the solvent dichloromethane played a key role for the reaction to proceed. The reaction is believed to be catalyzed by Lewis acid-assisted Bronsted acids, which were generated in situ from MX3 and water in the solvent.

关 键 词：Prins cyclization Lewis acids Bronsted acids enol ethers homogeneous catalysis 

分 类 号：TQ222.214[化学工程—有机化工] TQ423.2