A Novel Method for Biomimetic Synthesis of Mannich Bases  

作　　者：郭媛 安静 陆振欢 彭梦姣 

机构地区：[1]Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,College of Chemistry and Materials Science,Northwest University,Xi'an,Shaanxi 710069,China

出　　处：《Chinese Journal of Chemistry》2012年第7期1561-1564,共4页中国化学（英文版）

基　　金：Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc.201100628 or from the author.Acknowledgement We are very grateful for the support of this work from the National Natural Science Foundation of China （Nos. 20802056, 21072158） and the Special Foundation of the Education Committee of Shaanxi Province （No. 09JK750）.

摘　　要：Since the early studies of Mannich, Mannich reaction has become an important tool for the synthesis of new compounds. Mannich bases can be either directly employed or used as intermediates. In this work, the one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. 1,3-Dimethylimidazolidine as a new tetrahydrofolate coenzyme model at formaldehyde oxidation level was used to react with ketone having active hydrogen atoms and amine to give the corresponding Mannich base in good yield by a covert Mannich reaction. A novel method for biomimetic synthesis of various Mannich bases is provided.Since the early studies of Mannich, Mannich reaction has become an important tool for the synthesis of new compounds. Mannich bases can be either directly employed or used as intermediates. In this work, the one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. 1,3-Dimethylimidazolidine as a new tetrahydrofolate coenzyme model at formaldehyde oxidation level was used to react with ketone having active hydrogen atoms and amine to give the corresponding Mannich base in good yield by a covert Mannich reaction. A novel method for biomimetic synthesis of various Mannich bases is provided.

关 键 词：1 3-dimethylimidazolidine tetrahydrofolate coenzyme model Mannich reaction biomimetic synthesis 

分 类 号：TQ94[化学工程] TB321[一般工业技术—材料科学与工程]