Dimedone-catalyzed Addition of Amines into Cyano Group： Facile Synthesis of Thiazol-2-yl Substituted E-Acrylonitriles  

作　　者：朱伟军 屠兴超 冯惠 屠蔓苏 姜波 吴飞跃 屠树江 

机构地区：[1]School of Chemistry and Chemical Engineering,Laboratory of Green Synthetic Chemistry for Functional Materials,Xuzhou Normal University,Xuzhou,Jiangsu 221116,China [2]School of Chemical Engineering and Technology,Xuzhou College of Industrial Technology,Xuzhou,Jiangsu 221000,China

出　　处：《Chinese Journal of Chemistry》2012年第7期1617-1623,共7页中国化学（英文版）

基　　金：Supporting information for this article is available On the WWW under http：Nd-xlcloi.orgi10. 1002/cjoc.201100719 or from the author.Acknowledgement We are grateful for financial support from the National Science Foundation of China （Nos. 21072163, 21102124）, PAPD of Jiangsu Higher Education Institutions, Jiangsu Science and Technology Support Program （No. BE2011045）, Science Foundation in Interdisciplinary Major Research Project of Xuzhou Normal University （No. 09XKXK01）, and the NSF of Jiangsu Education Committee （No. 11KJB 150016）.

摘　　要：An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and amines. The a-thiocyanate ketones were subjected with malononitrile to provide thiazol-2-ylidenemalononitrile derivatives, followed with various amines in the presence of dimedone to yield the final thiazol-2-yl substituted acrylonitrile derivatives.An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and amines. The a-thiocyanate ketones were subjected with malononitrile to provide thiazol-2-ylidenemalononitrile derivatives, followed with various amines in the presence of dimedone to yield the final thiazol-2-yl substituted acrylonitrile derivatives.

关 键 词：dimedone-catalyzed synthesis E-acrylonitriles addition reaction microwave heating HETEROCYCLES 

分 类 号：TQ225.241[化学工程—有机化工] TQ226.61