盐酸贝那普利联合泼尼松治疗小儿原发性肾病综合征临床研究  

Clinical research of benazepril hydrochloride combined with prednisone in treating child primary nephritic syndrome

作　　者：招军[1] 沈琪[1] 杨彤[1] 

机构地区：[1]广西医科大学第五附属医院,广西柳州545006

出　　处：《现代医药卫生》2012年第15期2246-2247,共2页Journal of Modern Medicine & Health

摘　　要：目的观察盐酸贝那普利联合泼尼松治疗原发性肾病综合征的疗效和安全性。方法将40例患者随机分为两组:治疗组20例服用盐酸贝那普利0.1～0.3 mg/(kg.d),泼尼松片2 mg/(kg.d);对照组20例服用泼尼松片2 mg/(kg.d),疗程8周。观察24 h尿蛋白定量、血肌肝、血清清蛋白及血钾等变化及不良反应情况。结果治疗4周后两组患者24 h尿蛋白定量、总有效率比较,差异有统计学意义(P<0.05),治疗前及治疗8周后两组患者24 h尿蛋白定量、总有效率比较,差异无统计学意义(P>0.05)。两组在治疗过程中,血清肌肝及血钾比较,差异无统计学意义(P>0.05)。结论盐酸贝那普利联合泼尼松治疗原发性肾病综合征安全,早期有效,其疗效优于单用泼尼松。Objective To observe the therapeutic effect and safety of benazepril hydrochloride combined with prednisone in treating primary nephritic syndrome（PNS）. Methods 40 patients with PNS were divided into two groups at random. The treatment group （20 cases） took benazepril hydrochloride 0.1-0.3 mg/（kg, d） plus prednisone 2 mg/（kg, d） and the control group （20 cases） took prednisone 2 mg/（kg.d） with the treatment course of 8 week. Urine protein,serum creatine,serum albumin, serum potassium and adverse reactions were observed. Results After 4-week therapy, 24 h urine protein and the total effective rate had statistical difference between two groups（P〈0.05 ）. There were no statistical difference in 24 h urine protein and the total effective rate before treatment and after 8-week treatment between two groups（P〉0.05 ）. Serum creatine and serum potassi- um had no statistical difference between two groups （P〉0.05）. Conclusion Benazepril hydrochloride combined with prednisone for treating PNS is safe and effective in early stage, and is superior to single prednisone.

关 键 词：抗高血压药 血管紧张素转换酶抑制药/治疗应用 泼尼松 治疗应用 药物疗法 联合 肾病综合征/药物疗法 盐酸贝那普利 儿童 

分 类 号：R692[医药卫生—泌尿科学]