氨基末端脑钠肽前体水平对冠心病合并代谢综合征患者远期心血管事件的预测意义  

The prognostic value for cardiovascular events of elevated NT-proBNP in coronary heart disease patients with metabolic syndrome

作　　者：陈群 吴长明 姜建平 岳玉国[2] 

机构地区：[1]浙江省荣军医院心内科,浙江省嘉兴314000 [2]武警浙江省总队医院心内科

出　　处：《中国基层医药》2012年第15期2244-2245,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省嘉兴市科技局科研项目（2010AY1054）

摘　　要：目的 探讨血浆氨基末端脑钠肽前体（NT-proBNP）对冠心病合并代谢综合征患者远期心血管事件的预测意义。方法 经冠状动脉造影证实的165例冠心病合并代谢综合征患者,在入院时测定NT-pro水平,通过2年随访,观察其对远期心血管事件的预测意义。结果 冠心病合并代谢综合征患者NT-proBNP水平显著高于合并稳定型心绞痛组（P〈0.01）。2年后共发生心血管事件45例,调整了高血压、糖尿病、吸烟、高敏C反应蛋白等传统危险因素后,Cox风险回归提示NT-proBNP〉111.58 ng/L是预测远期心血管事件的独立危险之一（相对危险度2.67,P〈0.01）。结论 NT-proBNP是冠心病合并代谢综合征患者发生远期心血管事件的独立危险因素之一。Objective To explore the prognostic value for cardiovascular events of elevated NT-proBNP in coronary heart disease（CHD） patients with metabolic syndrome（MS）.Methods The level of NT-proBNP was measured in 165 CHD patients with MS diagnosed by coronary angiography.After 2 years follow-up,we recorded the corresponding cardiovascular events in those patients.Results The NT-proBNP level was much higher in ACS group than that in SCHD group（P〈0.01）.There were totally 45 events after 2 years.After adjustment of traditional risk factors including hypertension,diabetes,smoking history and high sensitivity C reactive protein（hs-CRP）,Cox proportional hazard analysis indicated that high NT-proBNP level（〉111.58ng/L）was an independent risk factor for future events（relative risk 2.67,P〈0.01）.Conclusion Elevated NT-proBNP level might be one of the independent risk factor for cardiovascular events in CHD patiens with MS.

关 键 词：冠状动脉疾病 代谢综合征 氨基末端脑钠肽前体 心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病] R589[医药卫生—内科学]