不同剂量甲钴胺治疗慢性酒精中毒性周围神经病变85例疗效分析  

Effect of different dosage of mecobalamin in treating 85 patients with chronic alcoholic peripheral neuropathy

作　　者：古美颖[1] 

机构地区：[1]重庆三峡中心医院神经内科,重庆市404000

出　　处：《中国基层医药》2012年第15期2260-2261,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 观察不同剂量甲钴胺治疗酒精中毒性周围神经病变患者的疗效。方法 85例经确诊为酒精中毒性周围神经病变患者随机分为A组（29例）、B组（28例）和C组（28例）。除常规治疗外,A组予甲钴胺1500 μg加入0.9%氯化钠注射液250 ml中静脉滴注,1次/d;B组予甲钴胺500μg加入0.9%氯化钠注射液250 ml中静脉滴注,1次/d;C组不予甲钴胺。治疗4周后评价患者症状改善情况,比较正中神经和腓总神经的神经传导速度。结果 各组治疗后症状均有明显改善。其中A组和B组效果优于C组（P〈0.01）,而A组疗效又优于B组（P〈0.05）。三组神经传导速度提高明显（P〈0.05）,A组和B组改善优于C组（P〈0.05）,A组优于B组（P〈0.05）。结论 甲钴胺治疗酒精中毒性周围神经病变具有一定疗效,而大剂量使用的效果优于常规剂量。Objective To observe the effect of different dosage of mecobalamin in treating patients with chronic alcoholic peripheral neuropathy.Methods 85 patients with chronic alcoholic peripheral neuropathy were randomly divided into group A（n=29）,group B（n=28）and group C（n=28）.Patients of all 3 groups were treated with conventional therapy.In addition,mecobalamin 1500 μg intravenously guttae once a day,mecobalamin 500 μg intravenously guttae once a day were given to patients in group A and B,respectively.Patients in group C were not given mecobalamin.After 4 weeks,improving and nerve conductive velocity were assessed for comparison.Results After 4 weeks’ therapy,patients of all 3 groups were remarkably improved.Therapeutic effects of group A and B were better than group C（all P〈0.01）,and group A was better than group B（P〈0.05）.Nerve conductive velocity of patients in all 3 groups were raised markedly（P〈0.05）.Patients with mecobalamin therapy（patients in group A＆amp;B） showed significantly greater improvement in nerve conductive velocity（P〈0.05） and high dose group（group A） was better than group B（P〈0.05）.Conclusion Mecobalamin has a curative effect on chronic alcoholic peripheral neuropathy and high dose therapy is better than regular dose.

关 键 词：甲钴胺 周围神经病变 中毒性 酒精 神经传导速度 

分 类 号：R595.6[医药卫生—内科学]