谷氨酰胺强化的肠内营养对脓毒症患者免疫功能的影响  

Effect of glutamine-fortified enteral nutritional on immune function of septic patients

作　　者：胡志华[1] 陈勉[1] 陈伟[1] 

机构地区：[1]海南医学院附属医院重症医学科,海南海口570102

出　　处：《中国热带医学》2012年第6期722-724,共3页China Tropical Medicine

摘　　要：目的通过对比添加谷氨酰胺的肠内营养支持治疗,探讨其对脓毒症患者免疫功能的影响。方法收集2010～2011年确诊脓毒症并添加肠内营养治疗患者96例,其中给予谷氨酰胺强化(干预组)的48例,未给予谷氨酰胺(对照组)的48例,分别于入院第1、10d,测定两组患者淋巴细胞计数、IgG、IgA、IgM、CD4+、CD4+/CD8+值,并进行统计学分析。结果两组患者年龄、APACHEⅡ之间无差异性,治疗前两组淋巴细胞计数、IgG、IgA、IgM、CD4+、CD4+/CD8+无差异性,治疗10d后干预组的淋巴细胞(0.604±0.123)、IgG(11.71±1.71)、IgA(2.33±0.18)、CD4(36.11±2.151)增高,与对照组比较均有统计学意义(P<0.01)。结论谷氨酰胺强化的肠内营养治疗能提高脓毒症患者的免疫功能,改善脓毒症患者的预后。Objective To investigate the effect of glutamine-fortified enteral nutrition iscusses on immune function of septic patients.Methods Ninety-six sepsis patients collected during 2009~2010 were divided into group A and group B each consisted of 48 cases.Cases in group A were given glutamine-fortified nutrition and those in group B were not given glutamine fortified nutrition.The levels of lymphocyte count,IgG,IgA,IgM,CD4＋,CD4＋/CD8＋ value were determined respectively on the first day and tenth day of admission.The results were statistically analyzed.Results No significant differences were observed in age and APACHE Ⅱ score between the two groups.The levels of lymphocyte count,IgG,IgA,IgM,CD4＋,CD4＋/CD8＋ showed no significant differences before treatment,but ten days after treatment the levels of lymphocytes（0.604±0.123）,IgG（11.71±1.71）,IgA（2.33±0.18）,CD4＋（36.11±2.151）increased in group A（P0.001）.Conclusion Glutamine fortified enteral nutrition therapy can enhance the immune function of septic patients,improve the prognosis of septic patients.

关 键 词：谷氨酰胺 肠内营养 脓毒症 免疫功能 

分 类 号：R692.5[医药卫生—泌尿科学]