妊娠高血压疾病患者内脂素和MIF的含量变化  

Expression of visfatin and macrophage migration inhibitory factor(MIF) in peripheral blood and umbilical cord blood of patients with hypertensive disorders in pregnancy

作　　者：徐娟[1] 邱晓菲[1] 周永勤[1] 班开斌[1] 黄友敏[1] 

机构地区：[1]滕州市中心人民医院,山东滕州277500

出　　处：《中国热带医学》2012年第6期730-732,共3页China Tropical Medicine

摘　　要：目的研究妊娠期高血压疾病患者静脉血清及胎儿脐血中内脂素(visfatin)和巨噬细胞移动抑制因子(MIF)的含量变化及意义。方法采用酶联免疫吸附法(ELISA)进行Visfatin和MIF含量的测定,分别测定90例妊娠期高血压疾病患者(其中妊娠期高血压、轻度子痫前期、重度子痫前期各30例)及30例正常对照组产妇静脉血清及胎儿脐血中Visfatin和MIF的含量。结果 Visfatin和MIF在妊娠期高血压疾病组及对照组血清及胎儿脐血中均有表达。MIF在妊娠期高血压疾病各组血清中含量与对照组血清中的比较,有显著性差异(t=7.31,9.82,10.04,P均<0.05),同时重度子痫前期组比轻度子痫前期和妊娠期高血压组含量高(t=7.23,8.95,P均<0.05);轻度子痫前期组含量高于妊娠期高血压组(t=7.68,P<0.05)。妊娠期高血压疾病各组血清中Visfatin含量均比对照组血清中含量高(t=7.83,质9.85,10.51,P均<0.05),且重度子痫前期组高于轻度子痫前期、妊娠期高血压组(t=7.68,8.73,P均<0.05);轻度子痫前期组含量高于妊娠期高血压组(t=7.69,P<0.05)。妊娠期高血压疾病患者Visfatin和MIF含量呈正相关(r=0.67,P<0.01)。Visfatin和MIF在妊娠期高血压疾病各组胎儿脐血中的含量,差异无显著意义(P>0.05)。结论 Visfatin和MIF的高表达,说明妊娠期高血压疾病患者存在炎症损伤,且Visfatin和MIF在损伤过程中起作用。Objective To investigate the expression and significance of visfatin and macrophage migration inhibitory factor（MIF）in intravenous serum and umbilical cord blood of pregnancy-induced hypertension syndrome（PIH）patients. Methods Contents of visfatin and MIF in intravenous serum and umbilical cord blood of 90 PIH patients divided into gestational hypertension,mild and severe preeclampsia groups each including 30 patients were detected by enzyme-linked immunosorbent assay（ELISA） respectively.30 normal pregnant women were taken as control group. Results Visfatin and MIF expressed in both patients and controls.Serum contents of MIF in patients and controls had significant difference by comparison（t=7.31,9.82,10.04,all P0.05）.Moreover,there were differences in the contents among the three groups（t=7.23,8.95,7.68,all P0.05）.Serum contents of visfatin in patients and controls showed significant differences by comparison（t=7.83,9.85,10.51,all P0.05）.Moreover,there were differences in ontents among the three groups（t=7.68,8.73,7.69,all P0.05）.Contents of visfatin and MIF PIH syndrome patients showed a positive correlation（r=0.67,P0.01）.There were no significant differences in contents of visfatin and MIF in umbilical cord blood of PIH syndrome patients among three groups（P0.05）. Conclusion The high expression of visfatin and MIF in PIH syndrome patients indicates the injury of vascular endothelium cells and visfatin and MIF plays a role in the process of injury.

关 键 词：妊娠期高血压疾病 VISFATIN 巨噬细胞移动抑制因子 脐血 

分 类 号：R714.24[医药卫生—妇产科学]