促排卵药物治疗不孕不育症效果观察  

Effects of ovulation induction therapies on infertility patients

作　　者：马丽影[1] 项云改[1] 赵冬梅[1] 毛跟红[1] 李朋粉[1] 陶识博[1] 谭丽[1] 

机构地区：[1]郑州大学第二附属医院生殖中心,河南郑州450014

出　　处：《中国热带医学》2012年第6期733-734,739,共3页China Tropical Medicine

摘　　要：目的观察促排卵药物治疗不孕不育症的效果。方法回顾性分析363对不孕夫妇进行的723个宫腔内人工授精(IUI)周期,根据是否使用促排卵药物及应用促排卵药物的种类分为自然周期组(143对)、枸橼酸氯米芬(CC)组(40对)、尿促性腺激素(HMG)组(126对)及CC+HMG组(54对)促排周期组;各组患者均在排卵前1d、排卵后1d进行一次IUI治疗,比较各组的临床妊娠率、宫外孕率、多胎率及OHSS率。结果促排卵周期总妊娠率为14.5%,略高于自然周期组妊娠率(11.5%),差异无统计学意义(P>0.05)。但是促排卵周期中CC+HMG组的妊娠率22.7%(20/88),明显高于自然周期,差异有统计学意义(P<0.05);CC组的妊娠率为3.0%(2/66)(P<0.05)明显低于自然周期,差异有统计学意义(P<0.05);HMG组妊娠率为14.6%(40/274)与自然周期比较差异无统计学意义(P>0.05);4组宫外孕率、多胎率及卵巢过度刺激综合症的发生率均无明显差异(P>0.05)。结论 IUI治疗中,CC+HMG促排周期妊娠率高于自然周期,是较为理想的治疗方案。Objective To investigate the effect of ovulation induction therapies on infertility patients.Methods The 363 infertile couples treated for 723 IUI cycles were divided into natural cycle,clomiphene（CC） cycle,human menopausal gonadotropin（HMG） cycle and CC＋HMG cycle.The clinical pregnancy rate,abortion rate,multifetal pregnancy rate and ovarian hyperstimulation syndrome（OHSS） rate were compared among different groups.Results The pregnancy rate in the natural cycle was significantly lower than that of CC＋HMG cycle（P0.05）,and significantly higher than that of CC cycle（P0.05）.The ectopic pregnancy rate,multifetal pregnancy rate and OHSS rate showed no significant differences between the four groups（P0.05）.Conclusion The CC＋HMG cycle is an ideal treatment for achieving a higher pregnancy rate than the natural cycle in IUI.

关 键 词：宫腔内人工授精 自然周期 促排卵 妊娠率 多胎率 

分 类 号：R711.6[医药卫生—妇产科学]