肾病综合征的疾病构成:单中心临床研究  

The spectrum of nephrotic syndrome from a single-center clinical research

作　　者：史晓虎[1] 李文歌[1] 杨冠男[1] 邹古明[1] 芦建华[1] 

机构地区：[1]中日友好医院肾内科,北京100029

出　　处：《中日友好医院学报》2012年第4期195-198,共4页Journal of China-Japan Friendship Hospital

摘　　要：目的：探讨肾病综合征（NS）的疾病构成,为临床诊治提供数据。方法：调研中日友好医院肾内科2009年1月~2010年12月住院患者中全部NS患者的临床资料。结果 ：2年中在住院NS患者共282例,其中男158例,女性124例;患者年龄14~80岁,平均42.5±17.4岁;青年109例,中年119例,老年54例。282例NS患者中,伴高血压、糖尿病、慢性肾功能衰竭、急性衰竭者分别为87例、21例、31例、14例。其中184例进行了肾穿刺活检,青年患者（86例）肾脏病理前3位疾病是：局灶节段性肾小球硬化症（FSGS）24例、微小病变性肾病（MCD）21例、IgA肾病（IgAN）21例;中年患者（81例）肾脏病理前4位疾病分别是：原发性膜性肾病（MN）25例、FSGS 13例、继发性膜性肾病（SMN）12例、MCD 10例;老年患者（17例）肾脏病理前2位是：MN 9例、FSGS3例。结论：NS患者以中青年为主,常合并高血压、糖尿病、肾功能衰竭。青年患者肾脏病理类型以FSGS、MCD和IgAN肾病为主;中年患者以MN、FSGS和SMN为主;老年患者以MN和FSGS为主。Objective：To investigate the constitute of nephrotic syndrome（NS）to provide data for clinical diagnosis and treatment.Methods：A total of 282 cases in China-Japan Friendship Hospital from Jan.2009 to Dec.2010 were enrolled in this prospective study.Their clinical and pathological datas were prospectively analyzed.Results：During this period,there were 282 cases of NS,accounts for 17.2% in total hospitalization.There were 158 males and 124 females,half of them were from cities.The average age of NS patients was 42.5±17.4 years old.Among them,109 cases were youth（≤35 yr）,119 cases were middle-aged（36~59yr）and 54 cases the elder（≥60yr）.Eighty seven of patients with malignant hypertension and 21 cases were diagnosed with diabetes,31 and 14 cases with chronic renal failure and acute renal failure,respectively.There were 184 cases accepted renal pathological biopsy.There were 86 cases in the youth group which were composed by 24 cases of focal segmental glomerular sclerosis（FSGS）,21 cases of minimal change disease（MCD）,21 cases of IgA nephropathy（IgAN）,12 cases of secondary membranous nephropathy（SMN）,7 cases of others types.There were 81 cases in middle-aged group which was composed by 25 cases of membranous nephropathy（MN）,13 cases of FSGS,10 cases of MCD,12 cases of SMN and 21 cases of other types.Finally,there were 17 in the elder group which was composed by 9 cases of MN,3 cases of FSGS and 5 cases of other types.Conclusion：The NS patients mainly consisted of the youth and the middle-aged groups,in which hypertension and diabetes were usually found concurrently.In the youth group,the common renal pathological types were FSGS,MCD,IgAN.And in the middle-aged cases,MN,FSGS,SMN were the commonest types,while in elder group it mainly included MN and FSGS.

关 键 词：肾病综合征 肾脏病理 年龄 

分 类 号：R473.5[医药卫生—护理学]