甲巯咪唑致胆汁淤积性肝损害4例临床分析  

Clinical analysis of 4 cases with methimazole-induced cholestatic liver injury

作　　者：沈明艳 何一凡[2] 张金苹[2] 蔡晓频[2] 帅瑛[2] 

机构地区：[1]北京监狱局医院内科,北京100054 [2]中日友好医院内分泌科,北京100029

出　　处：《中日友好医院学报》2012年第4期199-201,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的:探讨甲巯咪唑致胆汁淤积性肝损害的临床特点。方法:回顾性分析2007年12月~2011年12月在中日友好医院住院治疗的4例甲巯咪唑致胆汁淤积性肝损害患者的临床资料。结果:3例患者为女性,1例男性,年龄15~53岁,黄疸在服用甲巯咪唑后的3~4周发生,甲巯咪唑的剂量均为30mg/d,停药15d^6周后肝功能恢复正常。结论:甲巯咪唑治疗甲亢可能发生胆汁淤积性肝损害,尤其是在开始药物治疗的4周内,临床应注意监测肝功能,通常停药后6周内肝功能恢复正常。Objective：To investigate the clinical features of methimazole-induced cholestatic liver injury.Methods：Clinical data of 4 cases diagnosed methimazole-induced cholestatic liver injury from Dec.2007 to Dec.2011 in China-Japan Friendship Hospital were retrospectively analyzed.Results：Three cases were 3 female,1 male patients,aged 15 to 53 years,jaundice occurred between 3 to 4 weeks after taking methimazole with a dose of 30mg/d.Liver function returned to normal between 15 days to 6 weeks after methimazole withdrawal.Conclusion：Cholestatic liver injury is an adverse effect of methimazole that occurred within the first 4 weeks of medication.Liver function usually returned to normal within 6 weeks after discontinuing drug therapy.

关 键 词：甲巯咪唑 胆汁淤积 肝损害 

分 类 号：R581.1[医药卫生—内分泌]