丹莪妇康煎膏对子宫内膜异位症模型大鼠血浆TXB_2和6-Keto-PGF_(1α)的影响  

The Effect of Dan'e Fukang Decocted Extract on TXB_2 and 6-Keto-PGF_(1α) of Endometriosis Rats

作　　者：贺克[1] 刘姣[2] 李彩霞[1] 刘丽华[1] 李清[2] 

机构地区：[1]石家庄市第四医院药学部,河北石家庄050011 [2]河北医科大学中医学院药学部,河北石家庄050091

出　　处：《药品评价》2012年第17期30-33,共4页Drug Evaluation

基　　金：河北省科学技术项目(10276105D-46)

摘　　要：目的:通过观察血浆TXB2和6-Keto-PGF1α的含量变化,探讨丹莪妇康煎膏抑制子宫内膜异位症模型大鼠疼痛的作用机理。方法:采用自体移植法建立子宫内膜异位症大鼠模型,将造模成功的大鼠随机分为模型组、孕三烯酮组、丹莪妇康煎膏高剂量组及低剂量组,另设假手术组。给药30天后,观察形态学改变,检测大鼠血浆血栓烷B2(TXB2)、6-酮-前列腺素F1α(6-Keto-PGF1α)含量。结果:丹莪妇康煎膏能够抑制异位子宫内膜组织生长,并能显著降低大鼠血浆TXB2(P<0.01)、明显升高血浆6-Keto-PGF1α含量(P<0.05)。结论:丹莪妇康煎膏可通过抑制异位子宫内膜生长,降低TXB2/6-Keto-PGF1α,抑制EMS盆腔疼痛。Objective ： To investigate the possible mechanism of Dan＇e Fukang decocted extract （DFD） on pelvic pain of endometriosis （EMS） rats. Methods： The EMS rats were made by implanted tunica intima method. Then rats were randomly divided into 5 groups, which include sham operation group, EMS model group, Gestrinone group, high dose DFD group and low dose DFD group. After continuously intragastric administration for 30 days, the morphological changes of ectopic endometrium tissue were observed, and the levels of plasma TXB2 and 6-Keto- PGF1a were detected. Results： DFD could inhibit the growth of ectopic endometrium tissue, and significantly decreased the levels of plasma TXB2 （P〈0.01）, increased the level of plasma 6-Keto-PGF1a （P〈0.05）. Conclusion： DFD has a better effect on pelvic pain in EMS rats through inhibiting the growth of ectopic endometrium tissue and regulating TXB2/6-Keto-PGF1a ratio.

关 键 词：丹莪妇康煎膏 子宫内膜异位症 血栓烷B2 6-酮-前列腺素F1Α 

分 类 号：R285.5[医药卫生—中药学]