中国汉族人群2型糖尿病与脂联素基因SNP-11377位点相关性的Meta分析  

A Meta-analysis on the association between adiponectin gene SNP-11377 and type 2 diabetes in Chinese Han population

作　　者：李显丽[1] 张瑛[1] 杨莹[1] 姚宇峰 史荔 杨曼[1] 陶文玉[1] 熊煜欣[1] 李奕平[1] 

机构地区：[1]云南省第二人民医院内分泌代谢科,昆明650021 [2]中国医学科学院北京协和医学生物学研究所

出　　处：《中国糖尿病杂志》2012年第8期561-564,共4页Chinese Journal of Diabetes

基　　金：云南省教育厅科学研究基金(09C0296);云南省科技厅-昆明医学院应用基础研究联合专项基金(2011FB226)

摘　　要：目的评价脂联素基因SNP-11377位点与T2DM的相关性。方法采用Meta分析评估SNP-11377位点与T2DM的相关性。异质性检验后采用M-H固定效应模型合并比值比(OR)值,并进行发表偏倚检验。结果 (1)共纳入10篇文献,其中病例组2831例、对照组3035例。(2)异质性检验显示,脂联素基因SNP-11377在各研究间是同质(I2=11.2%,P>0.05),各研究之间不存在异质性。(3)M-H固定效应模型进行数据合并,结果显示合并OR为1.09(95%CI为1.00～1.18,P=0.05)。(4)Begg和Egger偏倚分析均显示无明显发表偏倚。结论脂联素基因SNP-11377G等位基因可能与中国汉族人群T2DM的发病风险相关。Objective To investigate the association of SNP-11377 in adiponectin gene with type 2 diabetes mellitus （T2DM）. Methods The Meta-analysis was performed to assess the association of SNP-11377 in adiponectin gene with T2DM. Fixed effect model （M-H） was used to pool odd ratio （OR） after heterogeneity test, while the publication bias was calculated. Results （1） Ten case-control studies were included in the Meta-analysis, with a total of 2831 T2DM patients and 3035 controls. （2） The between-study heterogeneity of the adiponectin gene SNP-11377 was not significant （Iz = 11.2 ~, P~ 0. 05）. （3） All data were pooled by Fixed effect model and showed total OR= 1.09 （95 ~ CI..1.00~ 1.18, P：0.05）. （4） Publication bias was examined by the Begg＇ s funnel plot and Egger~ s test and no publication bias was observed. Conclusion SNP-11377 G allele may be associated with the increased T2DM risk in Chinese Han population.

关 键 词：糖尿病 2型 脂联素基因 单核苷酸多态性 META分析 

分 类 号：R587.1[医药卫生—内分泌]