白藜芦醇对非酒精性脂肪肝小鼠肝脏过氧化物酶体增殖物激活受体γ表达影响的研究  

Resveratrol improves hepatic PPARγ expression in mice with non-alcoholic fatty liver

作　　者：刘爱林[1] 陈璐璐 张皎月 郑涓 袁志军[1] 冯爱桥[1] 

机构地区：[1]孝感市中心医院,432100 [2]华中科技大学附属协和医院

出　　处：《中国糖尿病杂志》2012年第8期622-624,共3页Chinese Journal of Diabetes

基　　金：湖北省科技攻关计划资助项目(2007AA302B05)

摘　　要：目的观察白藜芦醇对非酒精性脂肪肝(NAFL)小鼠肝细胞PPARγ表达的影响。方法小鼠分为正常对照(NC)组、高脂喂养(HF)组和白藜芦醇干预(HF+Res)组。检测肝脏脂肪变性程度及PPARγ、脂肪酸结合蛋白(FABP)mRNA的表达。结果 HF+Res组肝细胞脂肪变较HF组减轻,同时PPARγ、FABP表达下降(P<0.01)。结论白藜芦醇改善NAFL的机制可能与下调肝脏PPARγ、FABP基因表达有关。Objective To investigate the effect of resveratrol on gene expression of peroxisome pro- lifemtor-activated receptors 7 （PPART） in mice with high fat diet-induced non-alcoholic fatty liver （NAFL）. Methods Thirty male C57BL/6J mice were assigned randomly to three groups with 10 in each： normal control （NC） group, high fat diet （HF） group and resveratrol treatment （HF＋Res） group. NC group was fed with normal diet. HF group and HF＋Res group were fed with high fat diet, while after 8 weeks, the HF＋Res group was fed with resveratrol. Hepatic steatosis and expressions of PPAR7 and FABP mRNA were observed. Results In the HFnURes group, the hepatic steatosis was alleviated and the expressions of PPAR7 and FABP mRNA were decreased as compared with the HF group （P〈0.01）. Conclusion The improvement of NAFL by resveratrol could be partly related to down regulating ex- pressions of PPAR7 and FABP in the liver.

关 键 词：非酒精性脂肪肝 白藜芦醇 过氧化物酶体增殖物激活受体Γ 

分 类 号：R285.5[医药卫生—中药学]