fMRI盲信号分离中的时间和空间独立成分分析法的时空特性比较  

Comparison of Spatiotemporal Characteristics of Spatial and Temporal Independent Component Analysis for Blind Source Separation in fMRI Data

作　　者：高欣[1] 边倩 熊金虎[3] 

机构地区：[1]中科院苏州生物医学工程技术研究所医学影像室,江苏苏州215163 [2]第二炮兵工程大学指挥自动化系,陕西西安710025 [3]爱荷华大学放射科

出　　处：《中国医疗设备》2012年第8期33-36,共4页China Medical Devices

基　　金：国家自然科学基金资助项目(81000651);江苏省自然科学基金资助项目(BK2010236);美国国家卫生研究所NIH基金资助项目(R21 MH 082187-01)

摘　　要：目的采用空间独立成分分析法(sICA)和时间独立成分分析法(tICA)对功能磁共振成像(fMRI)信号进行分离,比较信号间的时空特性对2种独立成分分析方法性能的影响。方法模拟fMRI数据,并将2组独立的信号以及它们的线性混合信号叠加到空间独立的区域,分别利用Infomax、Combi、FBSS和ICA-EMB 4种算法实现sICA和tICA,并对模拟数据中的3组信号进行提取和分离。结果 sICA只能分离空间独立且时间高度独立的信号,无法分离空间相关、时间独立的信号;tICA不仅能够准确分离空间和时间高度独立信号,而且能够准确分离空间高度相关、时间独立的信号,并将时间相关信号整体提取;FBSS和ICA-EMB 2种算法较Infomax和Combi性能稳定。结论空间或时间独立性假设违背到一定程度时,sICA和tICA对信号分离的结果存在差异。应根据需要选择适合的sICA或者tICA方法对fMRI数据进行处理。Objective Separate the fMRI signals by using spatial independent component ~nalysis （sICA） and temporal independent component analysis （tlCA）. Compare the spatiotemporal characteristics among signals which has effect to performance analysis of two kinds of independt signals. Method Simulate fMRI data. Two sets of independent signals and their linear mixture were added in spatially independent regions, slCA and tlCA were achieved by using respectively Infomax, Combi, FBSS and ICA-EMB. Then three sets of signals were applied to separate and extract from simulated fMRI. Results sJCA can only separate signals spatially independent and highly temporally independent, can not separate spatially correlated and temporally independent signals, tlCA is not only able to separate highly spatiaUy and temporally independent signals, but also able to successfully separate highly spatially correlated and temporally independent signals, moreover, it can integrally extract temporally correlated signals. FBSS and ICA-EMB algorithms are more stable than Infomax and Combi algorithms. Conclusion The assumption of spatial or temporal independence is violated to a certain degree. There are certain difference of performance between slCA and tlCA. It should be based on the characteristics of signals and requirement to select adaptive slCA or tlCA method to fulfill blind signal separation in fMRI data.

关 键 词：脑功能磁共振成像 独立成分分析法 空间独立成分分析法 时间独立成分分析法 信号分离 

分 类 号：R445.2[医药卫生—影像医学与核医学] TN911.72[医药卫生—诊断学]