2010年感染科抗菌药物应用调查分析  

Application of antibiotics in department of infectious diseases in 2010

作　　者：赵学群[1] 王萍[2] 

机构地区：[1]天津市第一中心医院感染科,天津300192 [2]天津市第一中心医院药剂科,天津300192

出　　处：《中华医院感染学杂志》2012年第15期3319-3321,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析临床应用抗菌药物的现状及合理性,为抗菌药物的干预研究提供理论依据。方法采用回顾性调查方法,随机抽取医院2010年1月1日-12月31日感染科病历93份,其中符合入选标准的有88份;对抗菌药物的使用情况进行统计分析。结果患者感染所患疾病主要是肺炎,占72.73%,其次是气管、支气管炎,占4.55%;抗菌药物使用费用占西药费用的59.65%,平均每例患者的日均抗菌药物费用为479.43元;254例次有用药指征,占100.00%;调查共涉及抗菌药物13类43种,使用较多的前3类为头孢菌素类、青霉素类和喹诺酮类,使用频次前5种为哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、左氧氟沙星、莫西沙星、美罗培南;254例次应用抗菌药物病例中,符合用药指南的有201例次,符合率为79.13%;有相应的病原学检查的有145例次,送检率为57.09%;联合用药为58.27%;药物不良反应有4例次。结论天津市第一中心医院感染科住院患者的抗菌药物应用基本合理,但仍然存在不规范的现象,主要表现在用法用量、频繁换药、药敏试验等方面,应加强抗菌药物的管理,发挥临床药师的作用,提高临床医师的用药水平。OBJECTIVE To investigate the patientsr information and the use of antibiotics, then analyze the rationality of antibiotics used in infectious disease department, so as to promote clinical reasonable use of antibiotics. METHODS A retrospective study was conducted, in which 88 infected cases in this hospital were randomly selected from 93 infected cases from Jan 1 to Dee 31 2010. Statistical analysis of the use of antibiotics was performed. RESULTS The most infectious diseases among the patients was pneumonia, accounting for 72.73 %, followed by bronchitis and tracheitis （4.550%） ; the cost of antibiotics accounted for 59.650% among the western drugs, the average of the daily cost of antibiotics was 479. 43 yuan; there were 254 case-time with medication indication, accounting for 100. 00%; there were totally 13 categories （43 types） of antibiotics investigated, the top 3 used antimierobial agents were cephalosporins, penicillins and quinolones, the top five frequency of using antibiotics were piperaciHin/tazobactam, cefeperozone/sulbactam, levofloxacin, moxifloxacin, and meropenem; there were 201 cases（79.13 %）who met the medication indications in 254 cases; there were 145 cases（57. 09%）who underwent etiological examination with the submission rate of 57. 09% 58. 27% of antimicrobial agents were combined use of antimicrobial agents; there were four cases with adverse drug reactions. CONCLUSION In this hospital, the antibiotic drug use is overall basically reasonable. However, there are some aspects which are not reasonable, such as the usage and dosage, frequent dressing changes, and drug susceptibility testing; the management and supervision of the antibiotics should be strengthened to promote rational use of antibiotics.

关 键 词：抗菌药物 合理应用 调查分析 

分 类 号：R978.1[医药卫生—药品]