女性尿液中阴道加德纳菌的实验室研究  

Laboratory study of the Gardnrella vaginallis isolated from urine of female patients

作　　者：陈建江[1] 陈国英[2] 单平囡[1] 寿叶女[1] 金月美[1] 于捷敏[1] 甄国栋[1] 王丽萍[1] 许德顺[1] 

机构地区：[1]中国医科大学绍兴医院检验科,浙江绍兴县312030 [2]绍兴文理学院附属医院肿瘤科,浙江绍兴312000

出　　处：《中华医院感染学杂志》2012年第15期3424-3426,共3页Chinese Journal of Nosocomiology

摘　　要：目的检测女性患者尿液中分离的加德纳菌(GVA)耐药性,探讨女性尿路GVA感染的流行病学特征。方法采用人血平皿对门诊及住院的女性尿路感染(UTIs)患者(A组)、非特异细菌性阴道病(BV)患者(B组)和体检女性(C组),3组共432份尿液标本进行K-B纸片琼脂扩散药敏试验。结果 A组263份尿液中,GVA阳性为11例,阳性率为4.18%,与C组比,OR值为1.67,B组BV阳性的129例中,GVA阳性24例,阳性率为18.60%,与C组比OR值为3.65;哌拉西林、头孢曲松及万古霉素系全敏感;较少耐药的有氨苄西林、头孢噻肟、头孢唑林。结论 BV阳性是女性尿路GVA感染的重要原因之一;青霉素类或第一代头孢菌素可作为经验性常规用药,可以有效控制GVA的尿路感染的流行。OBJECTIVE To detect the drug resistance of the Gardnerella vaginalis （GVA） isolated from the urine of the female patients, and to study the epidemiological features for urinary tract infections caused by GVA. METHODS GVA from 432 urine samples in group A （with urinary tract infections）, B（BV） and C （physical examination） were isolated, cultivated, identified or cultivated purely for the urine, the drug susceptibility testing was performed by agar diffusion method in Kirby-Bauer disc. RESULTS GVA positive cases were 11 （4. 18%） of 263 urine samples in A group as compared with C group with OR value of 1.67; GVA positive cases were 24 （18.60%） in 129 BV positive cases of B group as compared with C group with the OR value of 3. 65; GVA isolates were susceptible to piperacillin, ceftriaxone, and vaneomycin; the resistance rates to ampicillin, cefotaxine, and cefazoline were relatively low. CONCLUSION BV-positive is one of the important causes for the urinary tract infections in female; penicillins or first generation of eephalosporiens can be used for the experiential treatment, which can effectively control the prevalence of urinary tract infections caused by GVA.

关 键 词：尿路感染 阴道加德纳菌 药敏试验 

分 类 号：R375[医药卫生—病原生物学]