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机构地区:[1]山东省地矿职工医院内科,山东省济南250013 [2]安徽医科大学第三附属医院合肥市第一人民医院肿瘤科
出 处:《中国基层医药》2012年第16期2429-2430,共2页Chinese Journal of Primary Medicine and Pharmacy
摘 要:目的 探讨慢性阻塞性肺疾病(COPD)患者血清中内皮素-1(ET-1)、肿瘤坏死因子α(TNF-α)和细胞黏附分子-1(ICAM-1)水平变化及其临床意义。方法 选择80例COPD患者(其中急性加重期47例、缓解期33例)作为观察对象,以30例健康体检者作为对照,采用酶联免疫法(ELISA)检测血清中ET-1、TNF-α和ICAM-1水平,并分组比较。结果 COPD患者血清ET-1、TNF-α和ICAM-1水平明显高于对照组(t=4.896、4.621、4.231,均P<0.05),COPD急性加重期ET-1、TNF-α和ICAM-1水平明显高于缓解期(t=3.346、3.525、3.269,均P<0.05)。结论 ET-1、TNF-α和ICAM-1共同参与了COPD的发病机制,在气道炎性反应中起着重要作用。Objective To investigate the clinical significance of Endothelin-1,Tumor necrosis factor-α and Intercellular adhesion molecule-1 in the patients with chronic obstructive pulmonary disease(COPD).Methods The serum samples were prepared from 80 cases with COPD and 30 healthy persons.The levels of ET-1,TNF-α and ICAM-1 were measured by enzyme-linked immunosorbent assay(ELISA).Results Levels of ET-1,TNF-α and ICAM-1 in the COPD patients were higher than thosein the healthy cases(t=4.896,4.621,4.231,all P<0.05).Levels of ET-1,TNF-α and ICAM-1 in the period of AECOPD were higher than those in the cases of the COPD stable time(t=3.346,3.525,3.269,all P<0.05).Conclusion ET-1,TNF-α and ICAM-1 are involved in airway inflammation,ET-1,TNF-α and ICAM-1 not only take part in the acute inflammation in COPD,but also closely connected with clinic stages.
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