氯化锂对小鼠体细胞遗传毒性作用的实验研究  

Study on Genotoxic Effect of Lithium Chloride in Somatic Cell of Mice

作　　者：帕它木[1] 黄贤仪[1] 龚建福[1] 

机构地区：[1]新疆医科大学劳动卫生学教研室,乌鲁木齐市830054

出　　处：《工业卫生与职业病》2000年第4期213-215,共3页Industrial Health and Occupational Diseases

摘　　要：观察氯化锂的遗传毒性特征并对其毒作用机制做一初步探讨。以氯化锂为受试物 ,昆明种小鼠为受试对象 ,分低 (2 2 5mg/kg)、中 (75 0mg/kg)、高 (2 2 5 0mg/kg) 3个不同剂量组进行小鼠体细胞遗传毒性试验。氯化锂经口灌胃染毒后 ,小鼠骨髓细胞染色体畸变率增高 (P <0 0 5 ) ;骨髓细胞微核率、胎肝细胞微核率增高 (P <0 0 5 ,P <0 0 1)。结果表明 。To study the genotoxic effect of lithium chloride in somatic cells of Kunmin mice,genotoxic tests on somatic cells(bone marrow cells and embryonic liver cells)were conducted.The results showed that the frequency of chromosome aberrations and micronucleus in bone marrow cells of high dose group(225 0 mg/kg LiCl)was significantly increased,the frequency of micronucleus in embryonic liver cells was significantly increased too.These results suggested that certain dose of lithium chloride might cause chromosome damage on somatic cells of Kunmin mice.

关 键 词：氯化锂 体细胞 遗传毒性 实验研究 

分 类 号：R135.1[医药卫生—劳动卫生] R994.6[医药卫生—公共卫生与预防医学]