冠心病介入治疗后再狭窄因素分析  

Risk Factors of Coronary Heart Disease in Correlation with Restenosis after Transluminal Coronary Angioplasty and Stenting

作　　者：苏静英[1] 蔡煦[1] 张大东[1] 沈卫峰[1] 于金德[1] 龚兰生[1] 

机构地区：[1]上海第二医科大学瑞金医院心脏科,上海200025

出　　处：《上海第二医科大学学报》2000年第4期293-295,298,共4页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的探讨冠心病介入治疗后再狭窄与冠心病易患因素关系。　方法冠心病介入治疗 44 0例中 ,选择连续 84例 (115个狭窄病变 )术后随访冠脉造影复查者 ,冠脉定量分析 (QCA)术前、术后和随访复查冠脉造影图象 ,并分析再狭窄与冠心病易患因素的关系。　结果患者 6个月再狭窄率为 40 .0 0 % ,多元回归分析再狭窄发生时间与吸烟史、多个易患因素、多支病变、病变类型和前降支病变呈正性相关 ,与支架置入呈负性相关。　结论冠心病易患因素与介入后再狭窄发生有密切的关系 ,特别是吸烟史。Objective The purpose of this study is to determinate whether risk factors such as cigarette smoking, diabetes mellitus, hypertension, hypercholesterolaemia, and family history of coronary artery disease (CAD) are correlated with restenosis after coronary angioplasty. Methods Quantitative coronary analysis was made and angiographic characteristics of the lesions were determined in 84 patients with the angiographies of pre-intervention, post-intervention among 440 patients who had undertaken coronary angioplasty or coronary stenting. Angiographic restenosis was defined as at least 50% diameter stenosis on the follow-up angiogram after the initial successful procedure. A multivariable Cox regression was performed to assess factors correlated with restenosis. Results The rate of restenosis of all patients was 40.00% during 6 months. The patients with coronary restenosis had more than one risk factor of CAD. Restenosis was correlated positively with pre-procedure smoking and other risk factors, multivessel disease, lesion types and LDA involvement negatively with stent implantation. Conclusion Restenosis after angioplasty might correlate significantly with pre-procedure smoking, and other risk factors of CAD.

关 键 词：冠心病 介入疗法 PTCA 再狭窄 支架置入 

分 类 号：R541.4[医药卫生—心血管疾病]