运动对大鼠下丘脑GnRH和β-EP含量的影响  

Effects of Exercise on GnRH and β-EP in Hypothalamus of Rats

作　　者：苑晓玲[1] 王蕴红[2] 邹延艾[2] 

机构地区：[1]北京军事医学科学院放射医学研究所 [2]北京体育师范学院,100088

出　　处：《中国运动医学杂志》2000年第3期270-272,共3页Chinese Journal of Sports Medicine

基　　金：健力宝运动医学青年科研基金

摘　　要：为探讨运动诱发月经周期紊乱乃至闭经的发生机制 ,设计了运动性闭经大鼠模型 ,利用免疫组织化学方法及图象分析系统 ,观察不同动情周期、不同训练强度时雌性大鼠下丘脑促性腺激素释放激素 (GnRH)和β -内啡呔 (β -EP)免疫反应阳性细胞的定量变化。结果提示 :急性运动时 ,下丘脑 β -EP含量降低 ,并在其他因素参与下 ,促使GnRH从下丘脑释放增多。长期力竭运动 ,下丘脑GnRH和 β -EP仍进行释放 ,但相互作用机制仍需探讨。To further study the effects of exercise on GnRH and β-EP in rats’ hypothalamus and the mechanism of athletic se- condary amenorrhea, a SD rat modal of immunocytochemistry and image analysis system was established.Different effects of different estrous cycle and intensity exercise on hypothalamus can be obtained. The result indicated that : intensive swimming exercise can reduce the positive substance of β-EP nervous cell in hypothalamus. With the other effects, the secretion of GnRH is increased. Prolonged exhausitive exercise can keep the secretion of β-EP and GnRH ,but the mechanism needs deep researching.

关 键 词：下丘脑 β-骨啡肽 免疫组织化学 GNRH 

分 类 号：R87[医药卫生—运动医学]