维生素C和维生素E对糖尿病大鼠非酶糖化和过氧化反应的影响  

Effects of vitamin E and vitamin C on nonenzymatic glycation and peroxidation in experimental diabetic rats

作　　者：钱萍萍[1] 程胜求[1] 郭俊生[1] 钮燕[2] 

机构地区：[1]第二军医大学军队卫生学教研室,上海200433 [2]海军医学研究所新药研究中心,上海200433

出　　处：《卫生研究》2000年第4期226-228,共3页Journal of Hygiene Research

基　　金：国家自然科学基金!资助 (No.396 70 6 36 )

摘　　要：以链脲佐菌素腹腔注射 SD大鼠建立糖尿病动物模型 ,在纯营养素饲料配方中补充维生素 C和 /或维生素 E,喂饲 5周 ,观察单独或联合补充维生素 C、维生素 E对糖尿病非酶糖化及过氧化的干预作用。结果显示维生素 C和 E联合补充可显著减少糖尿病大鼠血红蛋白、低密度脂蛋白及肾脏皮质的糖化终产物(AGEs)含量 ,同时显著降低脂质过氧化产物丙二醛 (MDA)水平 ,单独补充维生素 C或维生素 E能显著降低糖尿病大鼠血清及肾脏 MDA含量 ,但对糖化血红蛋白、糖化低密度脂蛋白及肾脏 AGEs含量作用不明显。提示维生素 C和 E的联合补充对糖尿病大鼠体内的非酶糖化和过氧化有明显的抑制作用 。SD rats were peritoneally injected with streptozotocin (STZ) to establish diabetic animal model.The changes of nonenzymatic glycation and peroxidation in rats supplemented with vitamin C and/ or vitamin E during five weeks were investigated.It was found that the glycated hemoglobin,glycated L DL, renal cortical AGEs and MDA in sera and renal cortex significantly decreased after supplementation of vitamins E and C jointly.It was also observed that the MDA in serum and the cortex of kidney but not glycated hemoglobin,glycated L DL and AGEs significantly decreased in the groups supplemented with vitamin C or vitamin E separately.The results suggested that jointsupplementation of vitamin C and vitamin E could inhibit nonenzym atic glycation obviously and peroxidation in diabetic rats and protect the kidney from damage under hyperglycem ia.

关 键 词：糖尿病 非酶糖化 过氧化 维生素E 维生素C 

分 类 号：R587.1[医药卫生—内分泌] R977.2[医药卫生—内科学]