心衰合剂对慢性心力衰竭患者N末端脑利钠肽前体的影响  

Effects of Xinshuai Mixture on N-terminal pro-BNP in Chronic Heart Failure

作　　者：李慧[1] 唐大晅[1] 郭维琴[1] 

机构地区：[1]北京东方医院

出　　处：《中西医结合心脑血管病杂志》2012年第8期902-903,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：北京中医药大学校级基金课题<心衰合剂对心衰患者B型钠尿肽水平的影响>

摘　　要：目的观察心衰合剂对慢性心力衰竭(心衰)患者N末端脑利钠肽前体(NT-proBNP)的影响。方法选取2009年1月—2009年12月在北京中医药大学东方医院心内科住院的心衰患者60例,按Framingham诊断标准进行评估,随机分为两组,各30例。治疗组在西医标准治疗心衰基础上加用心衰合剂;对照组仅用西医对心衰的标准治疗。治疗15d后重新评价心功能分级、射血分数(EF)以及NT-proBNP浓度。结果治疗后,治疗组NT-proBNP浓度较对照组有明显下降,差异有统计学意义(P<0.05),而心功能分级、EF值差异无统计学意义。结论 NT-proBNP较EF和心功能分级敏感性更高,是一个很好的评价中药治疗慢性心衰疗效的指标。Objective To investigate the effects of Xinshuai mixture on heart failure ejection fraction（EF） and N-terminal pro-brain natriuretic peptide（NT-proBNP） in patients with choric heart failure.Methods Sixty inpatients with heart failure were selected and divided into treatment group（n=30） received Xinshuai mixture and standard western medicine therapy and control group（n=30） receive standard western medicine therapy alone for 15 days.Heart function classification,EF and NT-pro BNP levels were reevaluated.Results At the end of treatment,comparing with the control group,NT-proBNP levels in treatment group was declined,and the differences were statistically significance.There were no statistically differences in New York Heart Association（NYHA） classifications and EF.Conclusion NT-proBNP was more sensitive than EF and NYHA,and it might be a good index to evaluate traditional Chinese drugs for treatment of chronic heart failure.

关 键 词：心衰合剂 心衰 N末端脑利钠肽前体 射血分数 心功能分级 

分 类 号：R541.6[医药卫生—心血管疾病] R289.5[医药卫生—内科学]