基于微流控芯片技术的天然产物活性成分筛选的研究  

Screening of active ingredients contained in natural products based on micro-fluidic chip technology

作　　者：李文娟[1,2] 徐溢[1,2,3] 范琪[1,2] 曹坤[1,2,3] 张庆[1,2] 王昌瑞[1,2,3] 钱伟[1,2] 张晓凤[1,2,3] 

机构地区：[1]重庆大学化学化工学院,重庆400030 [2]重庆大学新型微纳器件与系统技术重点学科实验室,重庆400030 [3]重庆大学微纳系统及新材料技术国际研发中心,重庆400030

出　　处：《中国中药杂志》2012年第16期2492-2497,共6页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2010ZX09401-306-1-5);全国博士学位论文作者专项资金项目(FSNEDD-200941);国家科技部-科技人员服务企业行动项目(2009GJF10037);重庆市科委科技计划项目攻关项目(CSTC;2010AC5050)

摘　　要：随着药物筛选技术的不断发展,新的筛选途径和技术不断涌现,使得药物筛选朝着快速、高效、高通量等方面不断发展。微流控分析技术具有的分析微型化、高通量化、可集成化和良好的生物相容性等特点,为天然产物活性成分的筛选提供了新的方法和技术平台,该文介绍了用于天然产物活性成分的多种筛选方法,重点综述了与细胞培养相结合的微流控芯片筛选技术及其特点,微流控芯片筛选技术平台的构成,以及其在天然产物活性成分筛选中的应用。With the constant development of the drug screening technology, new screening methods and techniques have came to the fore, driving drug screening to grow rapidly and efficiently with a high throughput. Characterized by micro-scale analysis, high throughput, inheritability and good biocompatibility, the micro-fluidic analytical technology provides a new method and technical platform for screening active ingredients from natural products. This essay introduces multiple methods used for screening acti＇~e ingredients from natural products and focuses on the micro-fluidic chip screening technology combined with cell culture and its characteristics, the composition of the platform of the micro-fluidic chip screening technology and its application in screening active ingredients from natural products.

关 键 词：药物筛选技术 天然产物 微流控芯片 细胞培养 高通量 高内涵 

分 类 号：TQ461[化学工程—制药化工] TN492[电子电信—微电子学与固体电子学]